Microbial biosynthesis of L-malic acid and related metabolic engineering strategies: advances and prospects

Z Wei, Y Xu, Q Xu, W Cao, H Huang… - Frontiers in Bioengineering …, 2021 - frontiersin.org
Malic acid, a four-carbon dicarboxylic acid, is widely used in the food, chemical and medical
industries. As an intermediate of the TCA cycle, malic acid is one of the most promising …

Microbial biosynthesis and secretion of l-malic acid and its applications

Z Chi, ZP Wang, GY Wang, I Khan… - Critical reviews in …, 2016 - Taylor & Francis
Abstract l-Malic acid has many uses in food, beverage, pharmaceutical, chemical and
medical industries. It can be produced by one-step fermentation, enzymatic transformation of …

Current advance in biological production of malic acid using wild type and metabolic engineered strains

Z Dai, H Zhou, S Zhang, H Gu, Q Yang, W Zhang… - Bioresource …, 2018 - Elsevier
Abstract Malic acid (2-hydroxybutanedioic acid) is a four-carbon dicarboxylic acid, which has
attracted great interest due to its wide usage as a precursor of many industrially important …

Polymalic acid fermentation by Aureobasidium pullulans for malic acid production from soybean hull and soy molasses: fermentation kinetics and economic analysis

C Cheng, Y Zhou, M Lin, P Wei, ST Yang - Bioresource Technology, 2017 - Elsevier
Polymalic acid (PMA) production by Aureobasidium pullulans ZX-10 from soybean hull
hydrolysate supplemented with corn steep liquor (CSL) gave a malic acid yield of∼ 0.4 g/g …

Taxonomy of Aureobasidium spp. and biosynthesis and regulation of their extracellular polymers

Y Li, Z Chi, GY Wang, ZP Wang, GL Liu… - Critical Reviews in …, 2015 - Taylor & Francis
The genus Aureobasidium spp. have been divided into three species, A. pullulans. A.
leucospermi and A. proteae, and A. pullulans has been known to have five varieties …

Engineering of primary carbon metabolism in filamentous fungi

T Chroumpi, MR Mäkelä, RP de Vries - Biotechnology advances, 2020 - Elsevier
Filamentous fungi are important industrial cell factories used for the production of a wide
range of enzymes and metabolites. Their primary metabolism is a significant source of …

Techno economic analysis of malic acid production using crude glycerol derived from waste cooking oil

B Bharathiraja, J Jayamuthunagai, R Sreejith… - Bioresource …, 2022 - Elsevier
In the present work, Aspergillus niger was employed to produce commercially valuable
malic acid from crude glycerol derived from waste cooking oil. Crude glycerol dosage, yeast …

Identification and engineering a C4-dicarboxylate transporter for improvement of malic acid production in Aspergillus niger

W Cao, L Yan, M Li, X Liu, Y Xu, Z **e, H Liu - Applied Microbiology and …, 2020 - Springer
Modification of C 4-dicarboxylate transport processes is an important strategy for the
development of efficient malic acid producing cell factory in Aspergillus niger. However …

Recent advances in microbial production of malic acid from renewable byproducts

J Iyyappan, G Baskar, E Gnansounou… - … Science and Bio …, 2019 - Springer
In the last few years, ecofriendly malic acid production has received a potential platform for
the bio-based chemicals to replace the dependency of fossil based resources. The main …

Integrated fermentative production and downstream processing of L-malic acid by Aspergillus wentii using cassava peel waste

D Gopaliya, S Zaidi, N Srivastava, B Rani… - Bioresource …, 2023 - Elsevier
Abstract L-malic acid (L-MA) is an industrially significant chemical with enormous potential.
The fungal cell factories could be exploited to harvest it on large scales. In our study …