Coumarin hybrids as novel therapeutic agents
Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …
[HTML][HTML] Tissue damage and oxidant/antioxidant balance
The oxidant/antioxidant balance in healthy tissues is maintained with a predominance of
antioxidants. Various factors that can lead to tissue damage disrupt the oxidant/antioxidant …
antioxidants. Various factors that can lead to tissue damage disrupt the oxidant/antioxidant …
Synthesis and pharmacological evaluation of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives as anti-inflammatory and analgesic agents
A series of novel 5-substituted-1-(phenylsulfonyl)-2-methylbenzimidazole derivatives have
been synthesized. The structures of these compounds were established by IR, 1H NMR …
been synthesized. The structures of these compounds were established by IR, 1H NMR …
Prodrug designing of NSAIDs
PK Halen, PR Murumkar, R Giridhar… - Mini reviews in …, 2009 - ingentaconnect.com
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic
inflammatory diseases suffer from several undesired side effects, the most important being …
inflammatory diseases suffer from several undesired side effects, the most important being …
Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides
The immobilization of the NSAID ibuprofen (Hibp) and the Cu (II)-ibp compound on
magnesium–aluminum layered double hydroxides (Mg 3 Al-LDH) is described. Ibuprofen …
magnesium–aluminum layered double hydroxides (Mg 3 Al-LDH) is described. Ibuprofen …
Synthesis and pharmacological evaluation of amide conjugates of NSAIDs with L-cysteine ethyl ester, combining potent antiinflammatory and antioxidant properties …
D Galanakis, AP Kourounakis, KC Tsiakitzis… - Bioorganic & medicinal …, 2004 - Elsevier
The synthesis and pharmacological evaluation of a series of amide derivatives of NSAIDs
with L-cysteine ethyl ester is described. The novel derivatives are potent antiinflammatory …
with L-cysteine ethyl ester is described. The novel derivatives are potent antiinflammatory …
Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect
A series of 5-methanesulphonamido benzimidazole derivatives were designed by
combining the structural features of clinically useful anti-inflammatory drugs (nimesulide and …
combining the structural features of clinically useful anti-inflammatory drugs (nimesulide and …
Coumarin–1, 2, 4-triazole hybrids: Recent advances in synthesis and medicinal applications
Abstract Coumarin and 1, 2, 4-triazole compounds have been widely used in drug design
and development due to their widespread biological applications. Combination of these two …
and development due to their widespread biological applications. Combination of these two …
Multi-target drug design approaches for multifactorial diseases: From neurodegenerative to cardiovascular applications
In multi-target drug design (MTD) medicinal chemistry aims to integrate multiple
pharmacophores into a single drug molecule in order to make it active on several molecular …
pharmacophores into a single drug molecule in order to make it active on several molecular …
Antioxidant serine-(NSAID) hybrids with anti-inflammatory and hypolipidemic potency
A series of L-serine amides of antioxidant acids, such as Trolox,(E)-3-(3, 5-di-tert-butyl-4-
hydroxyphenyl) acrylic acid (phenolic derivative of cinnamic acid) and 3, 5-di-tert-butyl-4 …
hydroxyphenyl) acrylic acid (phenolic derivative of cinnamic acid) and 3, 5-di-tert-butyl-4 …