Forty years since the structural elucidation of platelet-activating factor (PAF): historical, current, and future research perspectives

R Lordan, A Tsoupras, I Zabetakis, CA Demopoulos - Molecules, 2019 - mdpi.com
In the late 1960s, Barbaro and Zvaifler described a substance that caused antigen induced
histamine release from rabbit platelets producing antibodies in passive cutaneous …

Protective effect of olive oil microconstituents in atherosclerosis: emphasis on PAF implicated atherosclerosis theory

S Antonopoulou, CA Demopoulos - Biomolecules, 2023 - mdpi.com
Atherosclerosis is a progressive vascular multifactorial process. The mechanisms
underlining the initiating event of atheromatous plaque formation are inflammation and …

Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase

AD Tselepis, MJ Chapman - Atherosclerosis Supplements, 2002 - Elsevier
It is well established that inflammation is an integral feature of atherosclerosis and of the
cardiovascular diseases which it underlies. Oxidative stress is also recognized as a key …

COVID‐19, microthromboses, inflammation, and platelet activating factor

C Demopoulos, S Antonopoulou, TC Theoharides - Biofactors, 2020 - Wiley Online Library
Recent articles report elevated markers of coagulation, endothelial injury, and
microthromboses in lungs from deceased COVID‐19 patients. However, there has been no …

Oxidized phospholipids and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) in atherosclerotic cardiovascular disease: An update

D Pantazi, C Tellis, AD Tselepis - Biofactors, 2022 - Wiley Online Library
Inflammation and oxidative stress conditions lead to a variety of oxidative modifications of
lipoprotein phospholipids implicated in the occurrence and development of atherosclerotic …

[HTML][HTML] Invited review: The anti-inflammatory properties of dairy lipids

R Lordan, I Zabetakis - Journal of dairy science, 2017 - Elsevier
Dairy product consumption is often associated with negative effects because of its naturally
high levels of saturated fatty acids. However, recent research has shown that dairy lipids …

Τhe role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma

CC Tellis, AD Tselepis - Biochimica et Biophysica Acta (BBA)-Molecular …, 2009 - Elsevier
Platelet-activating factor (PAF) acetylhydrolase exhibits a Ca2+-independent phospholipase
A2 activity and degrades PAF as well as oxidized phospholipids (oxPL). Such phospholipids …

Platelet activating factor—a molecular link between atherosclerosis theories

CA Demopoulos, HC Karantonis… - European Journal of …, 2003 - Wiley Online Library
The most common causes of death in westernized societies remain heart disease and
stroke. For this reason the prevention of atherosclerosis is a major objective of modern …

PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma: catalytic characteristics and relation to the monocyte …

AD Tselepis, C Dentan, SAP Karabina… - … , and vascular biology, 1995 - ahajournals.org
In human plasma, platelet activating factor (PAF)–degrading acetylhydrolase
(acetylhydrolase) is principally transported in association with LDLs and HDLs; this enzyme …