Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that
represent potential sources of a wide variety of biologically active secreted products …

The acute symptoms of gout are triggered by the inflammatory response to monosodium
urate crystals, mediated principally by macrophages and neutrophils. Innate immune …

Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and
IL-36, play a pivotal role in the initiation and amplification of immune responses. However …

Cytokines activate or inhibit immune cell behavior and are thus integral to all immune
responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream …

Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin,
aims at barrier restoration. This process involves the coordinated efforts of several cell types …

Uric acid is a waste product of purine catabolism. This molecule comes to clinical attention
when it nucleates to form crystals of monosodium urate (MSU) in joints or other tissues, and …