Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M **ek, E Charpentier… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Fusions of Cas9 domains and nucleic acid-editing domains

DR Liu, AC Komor - US Patent 11,053,481, 2021 - Google Patents
2014-08-15 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

AAV delivery of nucleobase editors

DR Liu, JM Levy, WH Yeh - US Patent 11,306,324, 2022 - Google Patents
2018-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Cas variants for gene editing

DR Liu, AC Komor - US Patent 11,124,782, 2021 - Google Patents
2019-09-04 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Delivery system for functional nucleases

DR Liu, JA Zuris, DB Thompson - US Patent 10,682,410, 2020 - Google Patents
2016-06-22 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M **ek, K Chylinski… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription

JA Doudna, M **ek, E Charpentier… - US Patent …, 2019 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

CAS9 variants and uses thereof

DR Liu, JP Guilinger, DB Thompson - US Patent 10,858,639, 2020 - Google Patents
2016-12-07 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Nucleobase editors comprising nucleic acid programmable DNA binding proteins

DR Liu, AC Komor, L Chen, HA Rees - US Patent 11,268,082, 2022 - Google Patents
2019-03-13 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …

Switchable Cas9 nucleases and uses thereof

DR Liu, JH Hu - US Patent 10,597,679, 2020 - Google Patents
Some aspects of this disclosure provide compositions, methods, systems, and kits for
controlling the activity and/or improving the specificity of RNA-programmable …