1. Learn how the body disposes of alcohol and its metabolites. 2. Discern some of the factors
that influence this process. 3. Learn how alcohol influences the metabolism of nutrients and …

Much progress has been made in the understanding of the pathogenesis of alcoholic liver
disease, resulting in improvement of prevention and therapy, with promising prospects for …

Alcoholic liver disease includes steatosis, alcoholic hepatitis and cirrhosis. Other liver
diseases of genetic origin, but with a curious association with alcohol intake, are …

The reduction of short chain aldehydes to alcohols is a common biological reaction which
allows the disposal of reducing equivalents during anaerobic metabolism by bacteria, fungi …

Ethanol is hepatotoxic through redox changes produced by the NADH generated in its
oxidation via the alcohol dehydrogenase pathway, which in turn affects the metabolism of …

Liver mitochondria undergo dynamic alterations following chronic alcohol feeding to mice.
Intragastric alcohol feeding to mice resulted in 1) increased state III respiration (109 …

The pathogenesis of alcoholic liver disease (ALD) remains poorly understood but is likely a
multihit pathophysiological process. Here, we propose a hypothesis of how early …

Background/Aims An increase of ethanol metabolism and hepatic mitochondrial respiration
occurs in vivo after a single binge of alcohol. Here, our aim was to determine how ethanol …

The feeding of alcohol orally (Lieber-DeCarli diet) to rats has been shown to cause declines
in mitochondrial respiration (state III), decreased expression of respiratory complexes, and …

Chronic ethanol feeding to rats produces changes in hepatic mitochondria which persist in
the absence of ethanol metabolism. The integrity of isolated mitochondria is well preserved …