Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Klebsiella species cause a wide range of diseases including pneumonia, urinary tract
infections (UTIs), bloodstream infections and sepsis. These infections are particularly a …

Abstract Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is
required for TLR-mediated production of type-I IFN and several other proinflammatory …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

Diseases of the respiratory tract are among the leading causes of death in the world
population. Increasing evidence points to a key role of the innate immune system with its …

Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection
and inflammation to provide early defence against invading microorganisms. This function is …

Increasing antibiotic resistance among bacterial pathogens has rendered some infections
untreatable with available antibiotics. Klebsiella pneumoniae, a bacterial pathogen that has …

Respiratory infections and diseases are among the leading causes of death worldwide, and
effective treatments probably require manipulating the inflammatory response to pathogenic …

Carbapenem-resistant Klebsiella pneumoniae (CRKP) causes Gram-negative lung
infections and fatal pneumonic sepsis for which limited therapeutic options are available …