2D and 3D MALDI-imaging: conceptual strategies for visualization and data mining

H Thiele, S Heldmann, D Trede, J Strehlow… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Abstract 3D imaging has a significant impact on many challenges in life sciences, because
biology is a 3-dimensional phenomenon. Current 3D imaging-technologies (various types …

Spatial segmentation of imaging mass spectrometry data with edge-preserving image denoising and clustering

T Alexandrov, M Becker, S Deininger… - Journal of proteome …, 2010 - ACS Publications
In recent years, matrix-assisted laser desorption/ionization (MALDI)-imaging mass
spectrometry has become a mature technology, allowing for reproducible high-resolution …

Multicontrast MRI reconstruction with structure-guided total variation

MJ Ehrhardt, MM Betcke - SIAM Journal on Imaging Sciences, 2016 - SIAM
Magnetic resonance imaging (MRI) is a versatile imaging technique that allows different
contrasts depending on the acquisition parameters. Many clinical imaging studies acquire …

Structure tensor total variation

S Lefkimmiatis, A Roussos, P Maragos, M Unser - SIAM Journal on Imaging …, 2015 - SIAM
We introduce a novel generic energy functional that we employ to solve inverse imaging
problems within a variational framework. The proposed regularization family, termed as …

Applications of multivariate analysis and unsupervised machine learning to ToF-SIMS images of organic, bioorganic, and biological systems

W Gardner, DA Winkler, BW Muir, PJ Pigram - Biointerphases, 2022 - pubs.aip.org
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) imaging offers a powerful, label-
free method for exploring organic, bioorganic, and biological systems. The technique is …

Efficient spatial segmentation of large imaging mass spectrometry datasets with spatially aware clustering

T Alexandrov, JH Kobarg - Bioinformatics, 2011 - academic.oup.com
Motivation: Imaging mass spectrometry (IMS) is one of the few measurement technology s of
biochemistry which, given a thin sample, is able to reveal its spatial chemical composition in …

Near-optimal compressed sensing guarantees for total variation minimization

D Needell, R Ward - IEEE transactions on image processing, 2013 - ieeexplore.ieee.org
Consider the problem of reconstructing a multidimensional signal from an underdetermined
set of measurements, as in the setting of compressed sensing. Without any additional …