The relevance of the‐CF2H moiety has attracted considerable attention from organic
synthetic and medicinal chemistry communities, because this group can act as a more …

Currently, the chemistry of organofluorine compounds is a leading and rapidly develo**
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

As one of the most powerful trifluoromethylation reagents,(trifluoromethyl) trimethylsilane
(TMSCF3) has been widely used for the synthesis of fluorine-containing molecules …

In recent years, much interest has been paid to difluoromethylthiolated molecules as the
“SCF2” moiety is a key motif in drug and agrochemical research. Consequently, the …

The mechanism of CF2 transfer from TMSCF3 (1), mediated by TBAT (2–12 mol%) or by NaI
(5–20 mol%), has been investigated by in situ/stopped-flow 19F NMR spectroscopic …

Conspectus Recently, the strategic installation of a fluorine atom or a fluoroalkyl group site-
selectively at the specific position of the target molecule has become a routine approach and …

The mechanism of CF3 transfer from R3SiCF3 (R= Me, Et, i Pr) to ketones and aldehydes,
initiated by M+ X–(< 0.004 to 10 mol%), has been investigated by analysis of kinetics …

There have been significant developments in the area of perfluoroalkyl group transfer using
silicon reagents, specifically in nucleophilic trifluoromethylation. The mild and versatile …

Abstract The (benzenesulfonyl) difluoromethylsulfanyl (PhSO2CF2S) group is a valuable
substituent with specific properties which can provide access to new applications of …

A method for facile difluoromethylation of various thiols using (difluoromethyl)
triphenylphosphonium bromide under mild reaction conditions is presented. The …