Evolution and implications of de novo genes in humans
Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
non-coding sequences provide species with opportunities for adaptation. When aberrantly …
Nanostructures self-assembled from food-grade molecules with pH-cycle as functional food ingredients
Background Food ingredients fabricated with materials science and engineering principles
have unique functionalities serving various applications and purposes. With repeated …
have unique functionalities serving various applications and purposes. With repeated …
Experimental characterization of de novo proteins and their unevolved random-sequence counterparts
De novo gene emergence provides a route for new proteins to be formed from previously
non-coding DNA. Proteins born in this way are considered random sequences and typically …
non-coding DNA. Proteins born in this way are considered random sequences and typically …
The origin and structural evolution of de novo genes in Drosophila
Recent studies reveal that de novo gene origination from previously non-genic sequences is
a common mechanism for gene innovation. These young genes provide an opportunity to …
a common mechanism for gene innovation. These young genes provide an opportunity to …
Enzyme function and evolution through the lens of bioinformatics
Enzymes have been shaped by evolution over billions of years to catalyse the chemical
reactions that support life on earth. Dispersed in the literature, or organised in online …
reactions that support life on earth. Dispersed in the literature, or organised in online …
Insertions and deletions (indels): a missing piece of the protein engineering jigsaw
Over the years, protein engineers have studied nature and borrowed its tricks to accelerate
protein evolution in the test tube. While there have been considerable advances, our ability …
protein evolution in the test tube. While there have been considerable advances, our ability …
Random, de novo, and conserved proteins: how structure and disorder predictors perform differently
Understanding the emergence and structural characteristics of de novo and random proteins
is crucial for unraveling protein evolution and designing novel enzymes. However …
is crucial for unraveling protein evolution and designing novel enzymes. However …
Evolutionary trajectories of new duplicated and putative de novo genes
JC Montañés, M Huertas, X Messeguer… - Molecular biology and …, 2023 - academic.oup.com
The formation of new genes during evolution is an important motor of functional innovation,
but the rate at which new genes originate and the likelihood that they persist over longer …
but the rate at which new genes originate and the likelihood that they persist over longer …
Evolution of termination codons of proteins and the TAG-TGA paradox
M Trexler, L Bányai, K Kerekes, L Patthy - Scientific Reports, 2023 - nature.com
In most eukaryotes and prokaryotes TGA is used at a significantly higher frequency than
TAG as termination codon of protein-coding genes. Although this phenomenon has been …
TAG as termination codon of protein-coding genes. Although this phenomenon has been …
[HTML][HTML] Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning
Background: De novo protein coding genes emerge from scratch in the non-coding regions
of the genome and have, per definition, no homology to other genes. Therefore, their …
of the genome and have, per definition, no homology to other genes. Therefore, their …