Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

Adolescence is a transitional stage marked by continued brain development. This period is
accompanied by physical and neurochemical modifications in the shape and function of the …

The increased frequency of risk taking behavior combined with marked neuromaturation has
positioned adolescence as a focal point of research into the neural causes and …

This article is part of a Festschrift commemorating the 50th anniversary of the National
Institute on Alcohol Abuse and Alcoholism (NIAAA). Established in 1970, first as part of the …

Excessive alcohol use curtails longevity by rendering intoxicated individuals vulnerable to
heightened risk from accidents, violence, and alcohol poisoning, and makes chronically …

Subcortical brain morphometry matures across adolescence and young adulthood, a time
when many youth engage in escalating levels of alcohol use. Initial cross-sectional studies …

Cortical thickness changes dramatically during development and is associated with
adolescent drinking. However, previous findings have been inconsistent and limited by …

Abstract Background Extracellular vesicles (EVs) are heterogeneous membrane vesicles
secreted by cells in extracellular spaces that play an important role in intercellular …

Adolescent intermittent ethanol (AIE) exposure, which models heavy binge ethanol intake in
adolescence, leads to a variety of deficits that persist into adulthood—including suppression …

Alcohol use is a growing global health concern and economic burden. Alcohol involvement
(ie, initiation, use, problematic use, alcohol use disorder) has been reliably associated with …