[HTML][HTML] Development and research progress of anti-drug resistant fungal drugs

X Cui, L Wang, Y Lue, C Yue - Journal of Infection and Public Health, 2022‏ - Elsevier
With the widespread use of immunosuppressive agents and the increase in patients with
severe infections, the incidence of fungal infections worldwide has increased year by year …

[HTML][HTML] A decade of antifungal leads from natural products: 2010–2019

M Aldholmi, P Marchand, I Ourliac-Garnier, P Le Pape… - Pharmaceuticals, 2019‏ - mdpi.com
In this review, we discuss novel natural products discovered within the last decade that are
reported to have antifungal activity against pathogenic species. Nearly a hundred natural …

In the fungus where it happens: history and future propelling Aspergillus nidulans as the archetype of natural products research

LK Caesar, NL Kelleher, NP Keller - Fungal Genetics and Biology, 2020‏ - Elsevier
In 1990 the first fungal secondary metabolite biosynthetic gene was cloned in Aspergillus
nidulans. Thirty years later,> 30 biosynthetic gene clusters (BGCs) have been linked to …

Biosynthetic strategies for tetramic acid formation

X Mo, TAM Gulder - Natural Product Reports, 2021‏ - pubs.rsc.org
Covering: up to the end of 2020 Natural products bearing tetramic acid units as part of
complex molecular architectures exhibit a broad range of potent biological activities. These …

Recent progress in research on mitochondrion-targeted antifungal drugs: a review

Y Qin, J Wang, Q Lv, B Han - Antimicrobial Agents and …, 2023‏ - journals.asm.org
Fungal infections, which commonly occur in immunocompromised patients, can cause high
morbidity and mortality. Antifungal agents act by disrupting the cell membrane, inhibiting …

Anticancer fungal natural products: Mechanisms of action and biosynthesis

S Yuan, JV Gopal, S Ren, L Chen, L Liu… - European Journal of …, 2020‏ - Elsevier
Many fungal metabolites show promising anticancer properties both in vitro and in animal
models, and some synthetic analogs of those metabolites have progressed into clinical …

Bioproduction process of natural products and biopharmaceuticals: Biotechnological aspects

I Süntar, S Çetinkaya, ÜS Haydaroğlu… - Biotechnology …, 2021‏ - Elsevier
Decades of research have been put in place for develo** sustainable routes of
bioproduction of high commercial value natural products (NPs) on the global market. In the …

Development of a quinic acid-induced CRISPR/Cas9 genome editing system and its application for the activation of ilicicolin H biosynthesis in Trichoderma reesei

L Wang, J Liu, J Tang, Y Dang, L Sun, B Liu, H Li… - International Journal of …, 2024‏ - Elsevier
The CRISPR/Cas9 genome editing tool has been extensively utilized in filamentous fungi,
including Trichoderma reesei. However, most existing systems employ constitutive …

FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution

GA Vignolle, D Schaffer, L Zehetner… - PLoS computational …, 2021‏ - journals.plos.org
Secondary metabolites (SMs) are a vast group of compounds with different structures and
properties that have been utilized as drugs, food additives, dyes, and as monomers for novel …

Genome Characteristics of the Endophytic Fungus Talaromyces sp. DC2 Isolated from Catharanthus roseus (L.) G. Don

ND Quan, NL Nguyen, TTH Giang, NTT Ngan, NT Hien… - Journal of Fungi, 2024‏ - mdpi.com
Talaromyces sp. DC2 is an endophytic fungus that was isolated from the stem of
Catharanthus roseus (L.) G. Don in Hanoi, Vietnam and is capable of producing vinca …