Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis

M Furue - International journal of molecular sciences, 2020 - mdpi.com
Atopic dermatitis (AD) is an eczematous, pruritic skin disorder with extensive barrier
dysfunction and elevated interleukin (IL)-4 and IL-13 signatures. The barrier dysfunction …

[HTML][HTML] Aryl hydrocarbon receptor and intestinal immunity

B Lamas, JM Natividad, H Sokol - Mucosal immunology, 2018 - Elsevier
Aryl hydrocarbon receptor (AhR) is a member of the basic helix–loop–helix–(bHLH)
superfamily of transcription factors, which are associated with cellular responses to …

[HTML][HTML] What are the 100 most cited fungal genera?

CS Bhunjun, YJ Chen, C Phukhamsakda… - Studies in …, 2024 - ingentaconnect.com
The global diversity of fungi has been estimated between 2 to 11 million species, of which
only about 155 000 have been named. Most fungi are invisible to the unaided eye, but they …

Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor

A Uberoi, C Bartow-McKenney, Q Zheng, L Flowers… - Cell host & …, 2021 - cell.com
The epidermis forms a barrier that defends the body from desiccation and entry of harmful
substances, while also sensing and integrating environmental signals. The tightly …

Aryl hydrocarbon receptor ligands in cancer: friend and foe

IA Murray, AD Patterson, GH Perdew - Nature Reviews Cancer, 2014 - nature.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is best
known for mediating the toxicity and tumour-promoting properties of the carcinogen 2, 3, 7, 8 …

Malassezia ecology, pathophysiology, and treatment

B Theelen, C Cafarchia, G Gaitanis… - Medical …, 2018 - academic.oup.com
Malassezia are lipid dependent basidiomycetous yeasts that inhabit the skin and mucosa of
humans and other warm-blooded animals, and are a major component of the skin …

Living in your skin: microbes, molecules, and mechanisms

MH Swaney, LR Kalan - Infection and immunity, 2021 - Am Soc Microbiol
Human skin functions as a physical, chemical, and immune barrier against the external
environment while also providing a protective niche for its resident microbiota, known as the …

Malassezia-Associated Skin Diseases, the Use of Diagnostics and Treatment

DML Saunte, G Gaitanis, RJ Hay - Frontiers in cellular and infection …, 2020 - frontiersin.org
Yeasts of the genus, Malassezia, formerly known as Pityrosporum, are lipophilic yeasts,
which are a part of the normal skin flora (microbiome). Malassezia colonize the human skin …

The aryl hydrocarbon receptor: connecting immunity to the microenvironment

R Shinde, TL McGaha - Trends in immunology, 2018 - cell.com
The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor and transcription factor
activated through cognate ligand binding. It is an important factor in immunity and tissue …

The role of Th17-related cytokines in atopic dermatitis

M Sugaya - International journal of molecular sciences, 2020 - mdpi.com
T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of
various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases …