The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

In the brain, increases in neural activity drive changes in local blood flow via neurovascular
coupling. The common explanation for increased blood flow (known as functional …

Neurovascular coupling (NVC) is important for brain function and its dysfunction underlies
many neuropathologies. Although cell-type specificity has been implicated in NVC, how …

The mammalian brain depends upon glucose as its main source of energy, and tight
regulation of glucose metabolism is critical for brain physiology. Consistent with its critical …

Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

Resting-state signals in blood-oxygenation-level-dependent (BOLD) imaging are used to
parcellate brain regions and define" functional connections" between regions. Yet a …

First introduced in the 1980s, laser speckle contrast imaging is a powerful tool for full-field
imaging of blood flow. Recently laser speckle contrast imaging has gained increased …

The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …

Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and
lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not …

Identification of the cellular players and molecular messengers that communicate neuronal
activity to the vasculature driving cerebral hemodynamics is important for (1) the basic …