Mutations in the epidermal growth factor receptor (EGFR) gene are commonly observed in
non-small-cell lung cancer (NSCLC), particularly in tumors of adenocarcinoma (ADC) …

The high mobility group protein 2 (HMGA2) regulates gene expression by binding to AT-rich
regions of DNA. Akin to other DNA architectural proteins, HMGA2 is highly expressed in …

Tissues are organized in cellular niches, the composition and interactions of which can be
investigated using spatial omics technologies. However, systematic analyses of tissue …

Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with
certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However …

Macrophages form a major cell population in the tumor microenvironment. They can be
activated and polarized into tumor-associated macrophages (TAM) by the tumor-derived …

Fibroblasts are poorly characterised cells that variably impact tumour progression. Here, we
use single cell RNA-sequencing, multiplexed immunohistochemistry and digital cytometry …

Environmental nutrient levels impact cancer cell metabolism, resulting in context-dependent
gene essentiality,. Here, using loss-of-function screening based on RNA interference, we …

Cuproptosis, a newly identified form of programmed cell death, plays vital roles in
tumorigenesis. However, the interconnectivity of cuproptosis and ferroptosis is poorly …

Abstract Motivation: The recently released Infinium HumanMethylation450 array (the
'450k'array) provides a high-throughput assay to quantify DNA methylation (DNAm) at∼ 450 …

Background Increasing evidence has demonstrated the functional relevance of long non-
coding RNAs (lncRNAs) to immunity regulation and the tumor microenvironment in non …