The polypharmacological effects of cannabidiol
Cannabidiol (CBD) is a major phytocannabinoid present in Cannabis sativa (Linneo, 1753).
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …
This naturally occurring secondary metabolite does not induce intoxication or exhibit the …
CB2 receptor in microglia: the guardian of self-control
JA Komorowska-Müller, AC Schmöle - International journal of molecular …, 2020 - mdpi.com
Microglia are key to maintaining the homeostasis of the brain. These immune cells of the
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …
brain can be our biggest ally in fighting infections, but can worsen pathology or hinder …
Progress in brain cannabinoid CB2 receptor research: From genes to behavior
The type 2 cannabinoid receptor (CB2R) was initially regarded as a peripheral cannabinoid
receptor. However, recent technological advances in gene detection, alongside the …
receptor. However, recent technological advances in gene detection, alongside the …
[HTML][HTML] Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system
D Jeremic, I Sanchez-Rodriguez… - Pharmacology & …, 2021 - Elsevier
G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …
CB2 receptor in the CNS: From immune and neuronal modulation to behavior
W Grabon, S Rheims, J Smith, J Bodennec… - Neuroscience & …, 2023 - Elsevier
Despite low levels of cannabinoid receptor type 2 (CB2R) expression in the central nervous
system in human and rodents, a growing body of evidence shows CB2R involvement in …
system in human and rodents, a growing body of evidence shows CB2R involvement in …
[HTML][HTML] Endocannabinoid signaling in adult hippocampal neurogenesis: A mechanistic and integrated perspective
Dentate gyrus of the hippocampus continuously gives rise to new neurons, namely, adult-
born granule cells, which contribute to conferring plasticity to the mature brain throughout …
born granule cells, which contribute to conferring plasticity to the mature brain throughout …
Targeting peripherally restricted cannabinoid receptor 1, cannabinoid receptor 2, and endocannabinoid-degrading enzymes for the treatment of neuropathic pain …
MZ Hossain, H Ando, S Unno, J Kitagawa - International journal of …, 2020 - mdpi.com
Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells
A Bernal‐Chico, V Tepavcevic, A Manterola, C Utrilla… - Glia, 2023 - Wiley Online Library
The discovery of cannabinoid receptors as the primary molecular targets of psychotropic
cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for …
cannabinoid Δ9‐tetrahydrocannabinol (Δ9‐THC) in late 1980s paved the way for …
[HTML][HTML] Cannabis, endocannabinoids and brain development: from embryogenesis to adolescence
The endocannabinoid signalling system (ECS) plays a critical role from the very beginning
of embryogenesis. Accordingly, the ECS is engaged early on in nervous system …
of embryogenesis. Accordingly, the ECS is engaged early on in nervous system …
Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice
Cannabinoids produce a number of central nervous system effects via the CB 2 receptor (CB
2 R), including analgesia, antianxiety, anti-reward, hypoactivity and attenuation of opioid …
2 R), including analgesia, antianxiety, anti-reward, hypoactivity and attenuation of opioid …