The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

“Suffering so great as I underwent cannot be expressed in words... but the blank whirlwind of
emotion, the horror of great darkness, and the sense of desertion by God and man, which …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

Volatile anaesthetics have historically been considered to act in a nonspecific manner on
the central nervous system,. More recent studies, however, have revealed that the receptors …

Glutamatergic and cholinergic dysfunction are well‐attested features of Alzheimer's disease
(AD), progressing with other pathological indices of the disorder and exacerbating neuronal …

The amino acid γ-aminobutyric-acid (GABA) prevails in the CNS as an inhibitory neurotrans-
mitter that mediates most of its effects through fast GABA-gated Cl−-channels (GABA AR) …

Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the
brainstem, and glycinergic synapses have a well-established role in the regulation of …

The discovery of general anaesthesia, over 150 years ago, revolutionised medicine. The
ability to render a patient unconscious and insensible to pain made modern surgery …

General anesthetic drugs interact with many receptors in the nervous system, but only a
handful of these interactions are critical for producing anesthesia. Over the last 20 years …