Tfos dews ii pathophysiology report

AJ Bron, CS de Paiva, SK Chauhan, S Bonini… - The ocular …, 2017 - Elsevier
Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

The role of salivary gland histopathology in primary Sjogren's syndrome: promises and pitfalls

FGM Kroese, EA Haacke… - Clinical and experimental …, 2018 - research.rug.nl
The formation of lymphomononuclear cell infiltrates organising as periductal infiltrates in the
salivary glands of patients with primary Sjogren's syndrome (pSS) is one of the hallmarks of …

A biomarker for lymphoma development in Sjogren's syndrome: salivary gland focus score

L Chatzis, AV Goules, V Pezoulas, C Baldini… - Journal of …, 2021 - Elsevier
The aim of this study is to explore the role of labial minor salivary gland (LMSG) focus score
(FS) in stratifying Sjögren's Syndrome (SS) patients, lymphoma development prediction and …

[HTML][HTML] TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes

MH Dezfulian, T Kula, T Pranzatelli, N Kamitaki… - Cell, 2023 - cell.com
CD4+ T cells play fundamental roles in orchestrating immune responses and tissue
homeostasis. However, our inability to associate peptide human leukocyte antigen class-II …

Lymphomagenesis in Sjögren's syndrome: predictive biomarkers towards precision medicine

AV Goules, AG Tzioufas - Autoimmunity reviews, 2019 - Elsevier
Sjögren's syndrome (SS) is characterized by B cell hyperactivity documented by the
production of plethora of autoantibodies and a strong tendency for NHL of B cell origin …

Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) …

E Pontarini, E Sciacca, F Chowdhury… - Arthritis & …, 2024 - Wiley Online Library
Objective This study aimed to identify peripheral and salivary gland (SG) biomarkers of
response/resistance to B cell depletion based on the novel concise Composite of Relevant …

A comprehensive review of autoantibodies in primary Sjögren's syndrome: clinical phenotypes and regulatory mechanisms

NC Kyriakidis, EK Kapsogeorgou, AG Tzioufas - Journal of autoimmunity, 2014 - Elsevier
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by periepithelial
lymphocytic infiltrates in affected tissues and the production of plethora of autoantibodies …

Renal involvement in primary Sjögren's syndrome

R Evans, A Zdebik, C Ciurtin, SB Walsh - Rheumatology, 2015 - academic.oup.com
SS is a prevalent and underdiagnosed systemic disease that primarily affects epithelial
tissue. It may affect renal function either as epithelial disease causing tubulointerstitial …

A review of salivary gland histopathology in primary Sjögren's syndrome with a focus on its potential as a clinical trials biomarker

BA Fisher, RM Brown, SJ Bowman… - Annals of the Rheumatic …, 2015 - ard.bmj.com
Salivary gland changes, characterised by a focal lymphocytic sialadenitits, play an important
role in the diagnosis of primary Sjögren's syndrome (PSS) and were first described over 40 …

Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging

KM Leehan, NP Pezant, A Rasmussen… - Clinical and …, 2017 - pmc.ncbi.nlm.nih.gov
Objective Evaluate the presence of minor salivary gland (SG) fibrosis in primary Sjögren's
syndrome (pSS) as a function of disease pathology or a consequence of ageing. Methods …