Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

SARS-CoV-2 is highly pathogenic in humans and poses a great threat to public health
worldwide. Clinical data shows a disturbed type I interferon (IFN) response during the virus …

In less than 20 years, three deadly coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-
2, have emerged in human population causing hundreds to hundreds of thousands of …

Type I and type III interferons (IFNs) are the frontline of antiviral defense mechanisms that
trigger hundreds of downstream antiviral genes. In this study, we observed that MERS-CoV …

The retinoic acid–inducible gene I (RIG-I)–like receptors (RLRs) RIG-I, MDA5, and LGP2
stimulate inflammatory and antiviral responses by sensing nonself RNA molecules produced …

Inflammation is a pathological hallmark associated with bacterial and viral infections,
autoimmune diseases, genetic disorders, obesity and diabetes, as well as environmental …

Objectives To investigate whether the onset of polymyositis (PM)/dermatomyositis (DM)-
associated interstitial lung disease (ILD) is influenced by season and residence in the …

Porcine epidemic diarrhea virus (PEDV) causes a porcine disease associated with swine
epidemic diarrhea. Different antagonistic strategies have been identified, and the …