Various stress factors leading to protein damage induce the activation of an evolutionarily
conserved cell protective mechanism, the heat shock response (HSR), to maintain protein …

Mitochondrial oxidative damage is a basic mechanism of aging, and multiple studies
demonstrate that this process is attenuated by calorie restriction (CR). However, the …

Autophagy is a highly conserved self-degradation process of eukaryotic cells which is
required for the effective elimination of damaged and unnecessary cytosolic constituents …

Mechanisms controlling development, growth, and metabolism are coordinated in response
to changes in environmental conditions, enhancing the likelihood of survival to reproductive …

Autophagy has an important function in degrading cytoplasmic components to maintain
cellular homeostasis, but is also required during development. The formation of the …

The transcription factor HSF‐1 (heat shock factor 1) acts as a master regulator of heat shock
response in eukaryotic cells to maintain cellular proteostasis. The protein has a protective …

Ageing has a huge impact on human health and economy, but its molecular basis–
regulation and mechanism–is still poorly understood. By today, more than three hundred …

Autophagy is a lysosomal-dependent degradation process of eukaryotic cells responsible
for breaking down unnecessary and damaged intracellular components. Autophagic activity …

Dietary restriction (DR) and reduced insulin growth factor (IGF) signaling extend lifespan in
Caenorhabditis elegans and other eukaryotic organisms. Autophagy, an evolutionarily …

4, 4-Dimethyl phytosterols possess two methyl groups at the carbon-4 atom of the aliphatic A-
ring. The methyl groups are crucial for the molecular recognition of endogenous and …