Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

Microbubbles (MBs) were observed for the first time in vivo as a curious consequence of
quick saline injection during ultrasound (US) imaging of the aortic root, more than 50 years …

Microbubble-enhanced ultrasound provides a noninvasive physical method to locally
overcome major obstacles to the accumulation of blood-borne therapeutics in the brain …

Focused ultrasound (FUS) in combination with systemically injected microbubbles can be
used to non-invasively open the blood-brain barrier (BBB) in targeted regions for a variety of …

Recently, emerging evidence has demonstrated that cavitation actually creates important
bidirectional channels on biological barriers for both intratumoral drug delivery and …

Microbubbles are 1–10 μm diameter gas-filled acoustically-active particles, typically
stabilized by a phospholipid monolayer shell. Microbubbles can be engineered through …

Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can
transiently increase the permeability of the blood-brain barrier (BBB) to enable targeted …

Surface tension provides microbubbles (MB) with a perfect spherical shape. Here, we
demonstrate that MB can be engineered to be nonspherical, endowing them with unique …

Drug-loaded nanoscale cavitation agents, called nanodroplets, are an attractive solution to
enhance and localize drug delivery, offering increased stability and prolonged half-life in …

The recent and exciting success of anti-inflammatory therapies for ischemic heart disease
(eg atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic …