The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Covering: 2012 to 2013. Previous review: Nat. Prod. Rep., 2013, 30, 694–752 This review
covers the literature on simple indole alkaloids and those with a nonrearranged …

N-Acyliminium ions are powerful reactive species for the formation of carbon–carbon and
carbon–heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium …

Medicinal plants are well-known in affording clinically useful agents, with rich medicinal
values by combining with disease targets through various mechanisms. Plant secondary …

Natural products and their analogues are significant sources of therapeutic lead
compounds. However, synthetic strategies for generating large collections of these …

A facile and straightforward method was developed to construct the fused tetracyclic 3-
spirooxindole skeleton, which exists widely in natural products. The formation of the …

Strychnofoline is a Strychnos alkaloid that has unique spirooxindole architecture and
possesses important anticancer activity. Here, we have, for the first time, reported the …

A mild, reductive spirocyclization of indole-linked amides and lactams for the efficient and
selective synthesis of aza-spirocyclic indoline products is described. The catalytic reductive …

The asymmetric total syntheses of (−)-rhynchophylline and (+)-isorhynchophylline were
achieved in 17 and 16 steps, respectively, from butanal and ethyl acrylate. Our synthesis …

A highly efficient cinchona alkaloid-derived squaramide catalysed asymmetric
Michael/cyclization cascade reaction of 4-arylmethylidene-2, 3-dioxopyrrolidines with 2 …