Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives
A Kumari, RK Singh - Bioorganic chemistry, 2019 - Elsevier
Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic
compound with wide ranges of pharmacological activities due to different mechanisms of …
compound with wide ranges of pharmacological activities due to different mechanisms of …
An overview of 1, 2, 3-triazole-containing hybrids and their potential anticholinesterase activities
Acetylcholine (ACh) neurotransmitter of the cholinergic system in the brain is involved in
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
learning, memory, stress responses, and cognitive functioning. It is hydrolyzed into choline …
Potential role of sulfur-containing antioxidant systems in highly oxidative environments
All forms of life maintain a reducing environment (homeostasis) within their cells.
Perturbations in the normal redox state can lead to an oxidative environment which has …
Perturbations in the normal redox state can lead to an oxidative environment which has …
Design, synthesis and biological evaluation of ciprofloxacin tethered bis-1, 2, 3-triazole conjugates as potent antibacterial agents
A series of new bis-1, 2, 3-triazole linked ciprofloxacin conjugates was designed,
synthesized and evaluated in vitro antibacterial activity against a panel of clinically relevant …
synthesized and evaluated in vitro antibacterial activity against a panel of clinically relevant …
Synthesis, molecular docking and DFT studies on biologically active 1, 4-disubstituted-1, 2, 3-triazole-semicarbazone hybrid molecules
Some biologically active semicarbazone-triazole hybrid molecules have been designed and
synthesized from semicarbazone linked terminal alkyne and aromatic azides via Cu (I) …
synthesized from semicarbazone linked terminal alkyne and aromatic azides via Cu (I) …
Chemical and biological evaluation of thiosemicarbazone-bearing heterocyclic metal complexes
Thiosemicarbazones (TSCNs) constitute a broad family of compounds (R1R2C= N-NH-C (S)-
NR3R4), particularly attractive because many of them display some biological activity …
NR3R4), particularly attractive because many of them display some biological activity …
New ursolic acid derivatives bearing 1, 2, 3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo
TY Zhang, CS Li, LT Cao, XQ Bai, DH Zhao, SM Sun - Molecular Diversity, 2022 - Springer
In order to discover novel anti-inflammatory agents, three series of compounds obtained by
appending 1, 2, 3-triazole moieties on ursolic acid were designed and synthesized. All …
appending 1, 2, 3-triazole moieties on ursolic acid were designed and synthesized. All …
Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a/β-catenin pathway
Obesity and dyslipidemia is the two facet of metabolic syndrome, which needs further
attention. Recent studies indicate triazole and indole derivatives have remarkable anti …
attention. Recent studies indicate triazole and indole derivatives have remarkable anti …
Efficient click chemistry towards fatty acids containing 1, 2, 3-triazole: Design and synthesis as potential antifungal drugs for Candida albicans
Candida is an important opportunistic human fungal pathogen. The cis-2-dodecenoic acid
(BDSF) showing in vitro activity of against C. albicans growth, germ-tube germination and …
(BDSF) showing in vitro activity of against C. albicans growth, germ-tube germination and …
Azide-enolate 1, 3-dipolar cycloaddition in the synthesis of novel triazole-based miconazole analogues as promising antifungal agents
D González-Calderón, MG Mejía-Dionicio… - European Journal of …, 2016 - Elsevier
Abstract Seven miconazole analogs involving 1, 4, 5-tri and 1, 5-disubstituted triazole
moieties were synthesized by azide-enolate 1, 3-dipolar cycloaddition. The antifungal …
moieties were synthesized by azide-enolate 1, 3-dipolar cycloaddition. The antifungal …