The formation of functional neural circuits in the vertebrate central nervous system (CNS)
requires that appropriate numbers of the correct types of neuronal and glial cells are …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

In metazoans, lysosomes are the center for the degradation of macromolecules and play a
key role in a variety of cellular processes, such as autophagy, exocytosis and membrane …

The cerebellum develops from a restricted number of cell types that precisely organize to
form the circuitry that controls sensory-motor coordination and some higher-order cognitive …

The cerebellum is a pre-eminent model for the study of neurogenesis and circuit assembly.
Increasing interest in the cerebellum as a participant in higher cognitive processes and as a …

Cells differentiate when transcription factors bind accessible cis-regulatory elements to
establish specific gene expression programs. In differentiating embryonic stem cells …

Mutations in the X-linked MECP2 cause Rett syndrome, a devastating neurological disorder
typified by a period of apparently normal development followed by loss of cognitive and …

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and
orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a …

Hearing impairment due to the loss of sensory hair cells is permanent in humans.
Considerable interest targets the hair cell differentiation factor Atoh1 as a potential tool with …

Medulloblastoma (MB) is a highly malignant cerebellar tumor predominantly diagnosed
during childhood. Driven by pathogenic activation of sonic hedgehog (SHH) signaling, SHH …