The genetic architecture of Parkinson's disease

C Blauwendraat, MA Nalls, AB Singleton - The Lancet Neurology, 2020 - thelancet.com
Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …

The epidemiology of Parkinson's disease: risk factors and prevention

A Ascherio, MA Schwarzschild - The Lancet Neurology, 2016 - thelancet.com
Since 2006, several longitudinal studies have assessed environmental or behavioural
factors that seem to modify the risk of develo** Parkinson's disease. Increased risk of …

The clinical heterogeneity of Parkinson's disease and its therapeutic implications

JC Greenland, CH Williams‐Gray… - European Journal of …, 2019 - Wiley Online Library
Although Parkinson's disease (PD) is primarily a movement disorder, there are a range of
associated nonmotor symptoms, including cognitive impairment, depression and sleep …

[HTML][HTML] Lipid nanoparticles: promising treatment approach for Parkinson's disease

K Jagaran, M Singh - International Journal of Molecular Sciences, 2022 - mdpi.com
Parkinson's disease (PD), a neurodegenerative disorder, is a life-altering, debilitating
disease exhibiting a severe physical, psychological, and financial burden on patients …

Clinical and imaging markers of prodromal Parkinson's disease

E Hustad, JO Aasly - Frontiers in neurology, 2020 - frontiersin.org
The diagnosis of Parkinson's disease (PD) relies on the clinical effects of dopamine
deficiency, including bradykinesia, rigidity and tremor, usually manifesting asymmetrically …

Estimating the causal influence of body mass index on risk of Parkinson disease: a Mendelian randomisation study

AJ Noyce, DA Kia, G Hemani, A Nicolas, TR Price… - PLoS …, 2017 - journals.plos.org
Background Both positive and negative associations between higher body mass index (BMI)
and Parkinson disease (PD) have been reported in observational studies, but it has been …

Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda

R Grzadzinski, D Amso, R Landa, L Watson… - Journal of …, 2021 - Springer
Autism spectrum disorder (ASD) impacts an individual's ability to socialize, communicate,
and interact with, and adapt to, the environment. Over the last two decades, research has …

Diagnosis and management of Parkinson's disease

A Tarakad, J Jankovic - Seminars in neurology, 2017 - thieme-connect.com
Despite numerous efforts to identify specific and sensitive biomarkers, the diagnosis of
Parkinson's disease (PD) is still based on clinical criteria that include the presence of a …

α‐Synuclein Radiotracer Development and In Vivo Imaging: Recent Advancements and New Perspectives

OM Alzghool, G van Dongen… - Movement …, 2022 - Wiley Online Library
ABSTRACT α‐Synucleinopathies including idiopathic Parkinson's disease, dementia with
Lewy bodies and multiple systems atrophy share overlap** symptoms and pathological …

Development of early diagnosis of Parkinson's disease: Illusion or reality?

M Ugrumov - CNS neuroscience & therapeutics, 2020 - Wiley Online Library
The fight against neurodegenerative diseases, Alzheimer disease and Parkinson's disease
(PD), is a challenge of the 21st century. The low efficacy of treating patients is due to the late …