Microenvironment‐based diabetic foot ulcer nanomedicine

F Huang, X Lu, Y Yang, Y Yang, Y Li, L Kuai… - Advanced …, 2023 - Wiley Online Library
Diabetic foot ulcers (DFU), one of the most serious complications of diabetes, are essentially
chronic, nonhealing wounds caused by diabetic neuropathy, vascular disease, and bacterial …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

[HTML][HTML] Oral wound healing models and emerging regenerative therapies

AI Toma, JM Fuller, NJ Willett, SL Goudy - Translational Research, 2021 - Elsevier
Following injury, the oral mucosa undergoes complex sequences of biological healing
processes to restore homeostasis. While general similarities exist, there are marked …

[PDF][PDF] A combination therapy using electrical stimulation and adaptive, conductive hydrogels loaded with self‐assembled nanogels incorporating short interfering RNA …

H Lei, D Fan - Advanced Science, 2022 - Wiley Online Library
In addition to oxidative stress and impaired angiogenesis, the overexpression of
metalloproteinases (MMPs) and proinflammatory cytokines, which are promoted by …

Neuropathy and diabetic foot syndrome

M Volmer-Thole, R Lobmann - International journal of molecular sciences, 2016 - mdpi.com
Diabetic foot ulceration is a serious complication of diabetes mellitus worldwide and the
most common cause of hospitalization in diabetic patients. The etiology of diabetic foot …

Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights

D Baltzis, I Eleftheriadou, A Veves - Advances in therapy, 2014 - Springer
Diabetic foot ulcers (DFUs) are one of the most common and serious complications of
diabetes mellitus, as wound healing is impaired in the diabetic foot. Wound healing is a …

The role of bacterial biofilms in chronic infections

T Bjarnsholt - Apmis, 2013 - Wiley Online Library
Acute infections caused by pathogenic bacteria have been studied extensively for well over
100 years. These infections killed millions of people in previous centuries, but they have …

Current therapeutic strategies in diabetic foot ulcers

A Perez-Favila, ML Martinez-Fierro… - Medicina, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus,
with more than 400 million people diagnosed globally, and the condition is responsible for …

Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

Y Hu, H Li, X Lv, Y Xu, Y **e, L Yuwen, Y Song, S Li… - Nanoscale, 2022 - pubs.rsc.org
Diabetic wound infection is a common disease that has significantly reduced people's
quality of life. Although tremendous achievements have been made in clinical treatment, the …

Proteases and delayed wound healing

SM McCarty, SL Percival - Advances in wound care, 2013 - liebertpub.com
Significance: Proteases and their inhibitors contribute to the balance between extracellular
matrix (ECM) degradation and deposition, creating an equilibrium that is essential for the …