Mitotic kinesin-5 bipolar motor proteins perform essential functions in mitotic spindle
dynamics by crosslinking and sliding antiparallel microtubules (MTs) apart within the mitotic …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

Microtubules switch between growing and shrinking states, a feature known as dynamic
instability. The biochemical parameters underlying dynamic instability are modulated by a …

Background Midzones, also called central spindles, are an array of antiparallel microtubules
that form during cytokinesis between the separated chromosomes. Midzones can be …

Kinesin‐5 motors fulfil essential roles in mitotic spindle morphogenesis and dynamics as
slow, processive microtubule (MT) plus‐end directed motors. The Saccharomyces …

In this study, we examined the anaphase functions of the S. cerevisiae kinesin-5 homolog
Kip1. We show that Kip1 is attached to the mitotic spindle midzone during late anaphase …

Robert Blackwell, Christopher Edelmaier, Oliver Sweezy-Schindler, Adam Lamson, Zachary
Gergely, Eileen O'Toole, Ammon Crapo, Loren Hough, Richard McIntosh, Matthew Glaser …

The greatest mystery of life is how a single fertilized egg develops into a fully functioning,
sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory …

The bipolar kinesin-5 Cin8 switches from minus-to plus-end-directed motility under various
conditions in vitro. The mechanism and physiological significance of this switch remain …

The kinesin-5 Saccharomyces cerevisiae homologue Cin8 is shown here to be differentially
phosphorylated during late anaphase at Cdk1-specific sites located in its motor domain …