Obesity represents the single most important risk factor for early disability and death in
developed societies, and the incidence of obesity remains at staggering levels. CNS …

Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …

Diets rich in saturated fat produce inflammation, gliosis, and neuronal stress in the
mediobasal hypothalamus (MBH). Here, we show that microglia mediate this process and its …

The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase,
hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons …

Metabolic disorders, particularly aberrations in lipid homeostasis, such as obesity, type 2
diabetes mellitus, and hypertriglyceridemia often manifest together as the metabolic …

All organisms use fatty acids (FAs) for energy substrates and as precursors for membrane
and signaling lipids. The most efficient way to transport and store FAs is in the form of …

Lipoproteins in plasma transport lipids between tissues, however, only high-density
lipoproteins (HDL) appear to traverse the blood–brain barrier (BBB); thus, lipoproteins found …

It is generally understood that regular moderate to vigorous physical activity (MVPA)
promotes good health from head to toe. Evidence also supports the notion that too much …

Iron overload is closely associated with metabolic dysfunction. However, the role of iron in
the hypothalamus remains unclear. Here, we find that hypothalamic iron levels are …

Nutrient availability is critical for the physiological functions of all tissues. By contrast, an
excess of nutrients such as carbohydrate and fats impair health and shorten life due by …