Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Mental health care for older adults: recent advances and new directions in clinical practice and research

CF Reynolds 3rd, DV Jeste, PS Sachdev… - World …, 2022 - Wiley Online Library
The world's population is aging, bringing about an ever‐greater burden of mental disorders
in older adults. Given multimorbidities, the mental health care of these people and their …

Challenges and hopes for Alzheimer's disease

SA Tatulian - Drug discovery today, 2022 - Elsevier
Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Applications of machine learning to diagnosis and treatment of neurodegenerative diseases

MA Myszczynska, PN Ojamies, AMB Lacoste… - Nature reviews …, 2020 - nature.com
Globally, there is a huge unmet need for effective treatments for neurodegenerative
diseases. The complexity of the molecular mechanisms underlying neuronal degeneration …

Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease

M Kivipelto, F Mangialasche, T Ngandu - Nature Reviews Neurology, 2018 - nature.com
Research into dementia prevention is of paramount importance if the dementia epidemic is
to be halted. Observational studies have identified several potentially modifiable risk factors …

World‐Wide FINGERS Network: a global approach to risk reduction and prevention of dementia

M Kivipelto, F Mangialasche, HM Snyder… - Alzheimer's & …, 2020 - Wiley Online Library
Reducing the risk of dementia can halt the worldwide increase of affected people. The
multifactorial and heterogeneous nature of late‐onset dementia, including Alzheimer's …

Dementia prevention, intervention, and care

G Livingston, A Sommerlad, V Orgeta… - The …, 2017 - discovery.ucl.ac.uk
Acting now on dementia prevention, intervention, and care will vastly improve living and
dying for individuals with dementia and their families, and in doing so, will transform the …

Alzheimer's disease prevention: from risk factors to early intervention

M Crous-Bou, C Minguillón, N Gramunt… - Alzheimer's research & …, 2017 - Springer
Due to the progressive aging of the population, Alzheimer's disease (AD) is becoming a
healthcare burden of epidemic proportions for which there is currently no cure …

Rationale for a multi-factorial approach for the reversal of cognitive decline in Alzheimer's disease and MCI: a review

RV Rao, KG Subramaniam, J Gregory… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disease
typically characterized by memory loss, personality changes, and a decline in overall …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …