The role of proteoglycans in cancer metastasis and circulating tumor cell analysis

TD Ahrens, SR Bang-Christensen… - Frontiers in cell and …, 2020 - frontiersin.org
Circulating tumor cells (CTCs) are accessible by liquid biopsies via an easy blood draw.
They represent not only the primary tumor site, but also potential metastatic lesions, and …

[HTML][HTML] Iron and liver fibrosis: Mechanistic and clinical aspects

KJ Mehta, SJ Farnaud, PA Sharp - World journal of …, 2019 - ncbi.nlm.nih.gov
Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts
normal liver functionality. It is a pathological stage in several untreated chronic liver …

Genetics of gene expression and its effect on disease

V Emilsson, G Thorleifsson, B Zhang, AS Leonardson… - Nature, 2008 - nature.com
Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

UCHL1 as a novel target in breast cancer: emerging insights from cell and chemical biology

M Mondal, D Conole, J Nautiyal, EW Tate - British journal of cancer, 2022 - nature.com
Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor β (TGF-β) signaling

ST Christensen, SK Morthorst… - Cold Spring …, 2017 - cshperspectives.cshlp.org
Since the beginning of the millennium, research in primary cilia has revolutionized our way
of understanding how cells integrate and organize diverse signaling pathways during …

Human epidermal stem cell function is regulated by circadian oscillations

P Janich, K Toufighi, G Solanas, NM Luis, S Minkwitz… - Cell stem cell, 2013 - cell.com
Human skin copes with harmful environmental factors that are circadian in nature, yet how
circadian rhythms modulate the function of human epidermal stem cells is mostly unknown …

Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis

I Khan, N Kumar, I Pant, S Narra, P Kondaiah - PloS one, 2012 - journals.plos.org
Oral submucous fibrosis (OSF) is a chronic inflammatory disease characterized by the
accumulation of excess collagen, and areca nut chewing has been proposed as an …

Gene Expression Profiles of Luteal Phase Fallopian Tube Epithelium from BRCA Mutation Carriers Resemble High-Grade Serous Carcinoma

AA Tone, H Begley, M Sharma, J Murphy, B Rosen… - Clinical cancer …, 2008 - AACR
Purpose: To identify molecular alterations potentially involved in predisposition to adnexal
serous carcinoma (SerCa) in the nonmalignant fallopian tube epithelium (FTE) of BRCA1/2 …

Subendothelial stiffness alters endothelial cell traction force generation while exerting a minimal effect on the transcriptome

EE Bastounis, YT Yeh, JA Theriot - Scientific reports, 2019 - nature.com
Endothelial cells respond to changes in subendothelial stiffness by altering their migration
and mechanics, but whether those responses are due to transcriptional reprogramming …

Osteogenic differentiation and angiogenesis with cocultured adipose-derived stromal cells and bone marrow stromal cells

KI Kim, S Park, GI Im - Biomaterials, 2014 - Elsevier
The purpose of this study was to determine the influence of cocultured adipose-derived
stromal cells (ASCs) in enhancing the osteogenic differentiation and angiogenesis of bone …