Mesenchymal stem cell‐derived extracellular vesicles with high PD‐L1 expression for autoimmune diseases treatment

F Xu, Z Fei, H Dai, J Xu, Q Fan, S Shen… - Advanced …, 2022 - Wiley Online Library
Autoimmune diseases are the third most common disease influencing the quality of life of
many patients. Here, a programmed cell death‐ligand 1+(PD‐L1) mesenchymal stem cell …

Proliferation of monocytes and macrophages in homeostasis, infection, injury, and disease

J Pang, TJ Koh - Journal of Leukocyte Biology, 2023 - academic.oup.com
Monocytes (Mo) and macrophages (Mφ) play important roles in the function of tissues,
organs, and systems of all animals during homeostasis, infection, injury, and disease. For …

Research progress in cell therapy for oral diseases: Focus on cell sources and strategies to optimize cell function

J Wang, Z Zhao, K Yang, Y Bai - Frontiers in Bioengineering and …, 2024 - frontiersin.org
In recent years, cell therapy has come to play an important therapeutic role in oral diseases.
This paper reviews the active role of mesenchymal stem cells, immune cell sources, and …

A DNA nanodevice for map** sodium at single-organelle resolution

J Zou, K Mitra, P Anees, D Oettinger, JR Ramirez… - Nature …, 2024 - nature.com
Cellular sodium ion (Na+) homeostasis is integral to organism physiology. Our current
understanding of Na+ homeostasis is largely limited to Na+ transport at the plasma …

Exosomes derived from LPS-preconditioned bone marrow-derived MSC modulate macrophage plasticity to promote allograft survival via the NF-κB/NLRP3 signaling …

PY Zhang, P Wu, UZ Khan, Z Zhou, X Sui, C Li… - Journal of …, 2023 - Springer
Objectives This study investigated whether exosomes from LPS pretreated bone marrow
mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival. Methods The …

Engineering of dendritic cell bispecific extracellular vesicles for tumor-targeting immunotherapy

F Xu, D Jiang, J Xu, H Dai, Q Fan, Z Fei, B Wang… - Cell Reports, 2023 - cell.com
Advances in the development of therapeutic extracellular vesicles (EVs) for cancer
immunotherapy have allowed them to emerge as an alternative to cell therapy. In this proof …

Resolving monocytes generated through TRAM deletion attenuate atherosclerosis

S Geng, Y Zhang, Z Yi, R Lu, L Li - JCI insight, 2021 - pmc.ncbi.nlm.nih.gov
Polarization of low-grade inflammatory monocytes facilitates the pathogenesis of
atherosclerosis. However, underlying mechanisms as well as approaches for resolving …

[HTML][HTML] Self-renewal of macrophages: tumor-released factors and signaling pathways

S Filiberti, M Russo, S Lonardi, M Bugatti, W Vermi… - Biomedicines, 2022 - mdpi.com
Macrophages are the most abundant immune cells of the tumor microenvironment (TME)
and have multiple important functions in cancer. During tumor growth, both tissue-resident …

iPS cell–derived model to study the interaction between tissue macrophage and HIV-1

YM Eltalkhawy, N Takahashi, Y Ariumi… - Journal of Leukocyte …, 2023 - academic.oup.com
Despite effective antiretroviral therapy, HIV-1 persists in cells, including macrophages, which
is an obstacle to cure. However, the precise role of macrophages in HIV-1 infection remains …

Loss of CFTR function in macrophages alters the cell transcriptional program and delays lung resolution of inflammation

D Wellems, Y Hu, S Jennings, G Wang - Frontiers in Immunology, 2023 - frontiersin.org
Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in the
CF Transmembrane-conductance Regulator (CFTR) gene. The most severe pathologies of …