The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the
presence of autoantibodies against nuclear antigens, immune complex deposition, and …

Nucleic acid sensors, primarily TLR and RLR family members, as well as cGAS–STING
signalling, play a critical role in the preservation of cellular and organismal homeostasis …

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease with a complex
spectrum of cellular and molecular characteristics including several dramatic changes in the …

TLRs are a class of pattern recognition receptors (PRRs) that detect invading microbes by
recognizing pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement …

Recognition of pathogen-derived nucleic acids by pattern-recognition receptors (PRRs) is
essential for eliciting antiviral immune responses by inducing the production of type I …

Objective To analyze the expression, regulation, and biologic relevance of Toll‐like
receptors (TLRs) 1–10 in synovial and skin fibroblasts and to determine the expression …

Toll‐like receptors (TLRs) detect infections by highly conserved components of pathogens
that are either not present in our own cells or are normally sequestered in cellular …

Autoreactive B and T cells are present in healthy, autoimmunity-free individuals, but they are
kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) …

Investigations are needed to determine when and where RA begins, including
comprehensive prospective studies of individuals in the preclinical period of RA that can …