Mechanisms of sex differences in Alzheimer's disease

C Lopez-Lee, ERS Torres, G Carling, L Gan - Neuron, 2024 - cell.com
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …

Shedding light on biological sex differences and microbiota–gut–brain axis: a comprehensive review of its roles in neuropsychiatric disorders

P Shobeiri, A Kalantari, AL Teixeira, N Rezaei - Biology of sex differences, 2022 - Springer
Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …

Bacterial sensing via neuronal Nod2 regulates appetite and body temperature

I Gabanyi, G Lepousez, R Wheeler, A Vieites-Prado… - Science, 2022 - science.org
Gut bacteria influence brain functions and metabolism. We investigated whether this
influence can be mediated by direct sensing of bacterial cell wall components by brain …

Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia

HB Dodiya, HL Lutz, IQ Weigle, P Patel… - Journal of Experimental …, 2022 - rupress.org
We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut
microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology …

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

MN Ekwudo, C Gubert, AJ Hannan - The FEBS Journal, 2024 - Wiley Online Library
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

H Abou-El-Hassan, RM Rezende, S Izzy… - Nature …, 2023 - nature.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice

LM Cox, MJ Schafer, J Sohn, J Vincentini, HL Weiner… - Scientific reports, 2019 - nature.com
Alzheimer's disease (AD) affects an estimated 5.8 million Americans, and advanced age is
the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting …

Sex differences in the gut-brain axis: implications for mental health

C Holingue, AC Budavari, KM Rodriguez… - Current psychiatry …, 2020 - Springer
Abstract Purpose of Review The purpose of this article is to highlight how sex differences in
the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental …

Gut microbiota in women: The secret of psychological and physical well-being

G Marano, G Traversi, E Gaetani… - World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
The gut microbiota works in unison with the host, promoting its health. In particular, it has
been shown to exert protective, metabolic and structural functions. Recent evidence has …

Gut microbiota alterations and cognitive impairment are sexually dissociated in a transgenic mice model of Alzheimer's disease

D Cuervo-Zanatta, J Garcia-Mena… - Journal of Alzheimer's …, 2021 - content.iospress.com
Background: Normal aging is accompanied by cognitive deficiencies, affecting women and
men equally. Aging is the main risk factor for Alzheimer's disease (AD), with women having a …