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Mechanisms of sex differences in Alzheimer's disease
C Lopez-Lee, ERS Torres, G Carling, L Gan - Neuron, 2024 - cell.com
Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …
complex and multifactorial. The higher AD risk in women may serve as a clue to better …
Shedding light on biological sex differences and microbiota–gut–brain axis: a comprehensive review of its roles in neuropsychiatric disorders
Women and men are suggested to have differences in vulnerability to neuropsychiatric
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …
disorders, including major depressive disorder (MDD), generalized anxiety disorder (GAD) …
Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
I Gabanyi, G Lepousez, R Wheeler, A Vieites-Prado… - Science, 2022 - science.org
Gut bacteria influence brain functions and metabolism. We investigated whether this
influence can be mediated by direct sensing of bacterial cell wall components by brain …
influence can be mediated by direct sensing of bacterial cell wall components by brain …
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut
microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology …
microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology …
The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …
characterized by progressive movement disorder (including chorea), cognitive deficits …
Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …
Calorie restriction slows age-related microbiota changes in an Alzheimer's disease model in female mice
Alzheimer's disease (AD) affects an estimated 5.8 million Americans, and advanced age is
the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting …
the greatest risk factor. AD patients have altered intestinal microbiota. Accordingly, depleting …
Sex differences in the gut-brain axis: implications for mental health
Abstract Purpose of Review The purpose of this article is to highlight how sex differences in
the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental …
the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental …
Gut microbiota in women: The secret of psychological and physical well-being
The gut microbiota works in unison with the host, promoting its health. In particular, it has
been shown to exert protective, metabolic and structural functions. Recent evidence has …
been shown to exert protective, metabolic and structural functions. Recent evidence has …
Gut microbiota alterations and cognitive impairment are sexually dissociated in a transgenic mice model of Alzheimer's disease
Background: Normal aging is accompanied by cognitive deficiencies, affecting women and
men equally. Aging is the main risk factor for Alzheimer's disease (AD), with women having a …
men equally. Aging is the main risk factor for Alzheimer's disease (AD), with women having a …