In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

BACKGROUND It has long been thought that the factors affecting embryo and foetal
development were exclusively maternally derived; hence, if issues regarding fertility and …

Every cell must solve the problem of how to fold its genome. We describe how the folded
state of chromosomes is the result of the combined activity of multiple conserved …

Faithful DNA replication is essential for genome integrity,,–. Under-replicated DNA leads to
defects in chromosome segregation, which are common during embryogenesis,,–. However …

Mammalian gametogenesis involves dramatic and tightly regulated chromatin remodeling,
whose regulatory pathways remain largely unexplored. Here, we generate a comprehensive …

During meiosis, chromosomes exhibit dramatic changes in morphology and intranuclear
positioning. How these changes influence homolog pairing, alignment, and recombination …

Controlled assembly and disassembly of multi-protein complexes is central to cellular
signaling. Proteins of the widespread and functionally diverse HORMA family nucleate …

Interphase chromatin is hierarchically organized into higher-order architectures that are
essential for gene functions, yet the biomolecules that regulate these 3D architectures …

DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …

The spatial folding of chromosomes inside the nucleus has regulatory effects on gene
expression, yet the impact of genome reshuffling on this organization remains unclear. Here …