Variants in> 12 genes encoding sarcomeric proteins can cause various cardiomyopathies.
The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

Decreased left ventricle (LV) function caused by genetic mutations or injury often leads to
debilitating and fatal cardiovascular disease. LV cardiomyocytes are, therefore, a potentially …

Mechanotransduction refers to the ability of cells to sense mechanical stimuli and convert
them into biochemical signals. In this context, the key players are focal adhesions (FAs) …

Mechanical biomarkers distinguish health conditions through quantitative mechanical
measurements. The emergence and establishment of nanotechnology in the last decades …

Dilated cardiomyopathy (DCM) remains an enigmatic cardiovascular disease (CVD)
condition characterized by contractile dysfunction of the myocardium due to dilation of the …

Postural Orthostatic Tachycardia Syndrome (POTS) affects up to 1% of the US population,
predominantly women, and is characterized by a complex, elusive etiology and …

The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated
muscle. In this study, we sought to investigate the effects of an ACTN2 missense variant of …

The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to
contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to …

Titin, the so‐called “third filament” of the sarcomere, represents a difficult challenge for the
determination of damaging genetic variants. A single titin molecule extends across half the …