The evolving role of genetic tests in reproductive medicine
Infertility is considered a major public health issue, and approximately 1 out of 6 people
worldwide suffer from infertility during their reproductive lifespans. Thanks to technological …
worldwide suffer from infertility during their reproductive lifespans. Thanks to technological …
Congenital hypopituitarism during the neonatal period: epidemiology, pathogenesis, therapeutic options, and outcome
L Bosch i Ara, H Katugampola, MT Dattani - Frontiers in pediatrics, 2021 - frontiersin.org
Introduction: Congenital hypopituitarism (CH) is characterized by a deficiency of one or more
pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and …
pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and …
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
R Pfäffle, J Klammt - Best practice & research Clinical endocrinology & …, 2011 - Elsevier
The somatotropic axis is the central postnatal regulator of longitudinal growth. One of its
major components–growth hormone–is produced by the anterior lobe of the pituitary, which …
major components–growth hormone–is produced by the anterior lobe of the pituitary, which …
[HTML][HTML] Congenital hypopituitarism: various genes, various phenotypes
M Xatzipsalti, A Voutetakis… - Hormone and …, 2019 - thieme-connect.com
The ontogenesis and development of the pituitary gland is a highly complex process that
depends on a cascade of transcription factors and signaling molecules. Spontaneous …
depends on a cascade of transcription factors and signaling molecules. Spontaneous …
Combined pituitary hormone deficiency: current and future status
F Castinetti, R Reynaud, MH Quentien, N Jullien… - Journal of …, 2015 - Springer
Over the last two decades, the understanding of the mechanisms involved in pituitary
ontogenesis has largely increased. Since the first description of POU1F1 human mutations …
ontogenesis has largely increased. Since the first description of POU1F1 human mutations …
[HTML][HTML] Combined pituitary hormone deficiency caused by PROP1 mutations: update 20 years post-discovery
The first description of patients with combined pituitary hormone deficiencies (CPHD)
caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and …
caused by PROP1 mutations was made 20 years ago. Here we updated the clinical and …
The role of transcription factors implicated in anterior pituitary development in the aetiology of congenital hypopituitarism
The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis,
and is the end‐product of a carefully orchestrated pattern of expression of signalling …
and is the end‐product of a carefully orchestrated pattern of expression of signalling …
Pituitary stem cell regulation: who is pulling the strings?
B Cox, H Roose, A Vennekens… - Journal of …, 2017 - joe.bioscientifica.com
The pituitary gland plays a pivotal role in the endocrine system, steering fundamental
processes of growth, metabolism, reproduction and co** with stress. The adult pituitary …
processes of growth, metabolism, reproduction and co** with stress. The adult pituitary …
Association of Homozygous PROP1 Mutation in a Saudi Family with Combined Pituitary Hormone Deficiency
Background and Objectives: Combined pituitary hormone deficiency (CPHD) is a rare
heterogeneous disease. It is characterized by the deficiency of growth hormone (GH) and …
heterogeneous disease. It is characterized by the deficiency of growth hormone (GH) and …
Common and uncommon mouse models of growth hormone deficiency
Mouse models of growth hormone deficiency (GHD) have provided important tools for
uncovering the various actions of GH. Nearly 100 years of research using these mouse lines …
uncovering the various actions of GH. Nearly 100 years of research using these mouse lines …