The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …

RNA editing is a widespread post-transcriptional mechanism able to modify transcripts
through insertions/deletions or base substitutions. It is prominent in mammals, in which …

Background RNA editing at the Q/R site of GluA2 occurs with~ 99% efficiency in the healthy
brain, so that the majority of AMPARs contain GluA2 (R) instead of the exonically encoded …

In poikilotherms, temperature changes challenge the integration of physiological function.
Within the complex nervous systems of the behaviorally sophisticated coleoid cephalopods …

Background Metazoan adenosine-to-inosine (A-to-I) RNA editing resembles A-to-G mutation
and increases proteomic diversity in a temporal-spatial manner, allowing organisms …

ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate
adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects …

ABSTRACT Adenosine-to-inosine (A-to-I) RNA editing, mediated by metazoan ADAR
enzymes, is a prevalent post-transcriptional modification that diversifies the proteome and …

In situ capturing technologies add tissue context to gene expression data, with the potential
of providing a greater understanding of complex biological systems. However, splicing …

As one of the most prevalent RNA modifications in animals, adenosine-to-inosine (A-to-I)
RNA editing facilitates the environmental adaptation of organisms by diversifying the …