Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction

EC Kugler, J Greenwood… - Frontiers in Cell and …, 2021 - frontiersin.org
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease

D Kaur, V Sharma, R Deshmukh - Inflammopharmacology, 2019 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease that is of high importance to the
neuroscience world, yet the complex pathogenicity is not fully understood. Inflammation is …

Glial responses to implanted electrodes in the brain

JW Salatino, KA Ludwig, TDY Kozai… - Nature biomedical …, 2017 - nature.com
The use of implants that can electrically stimulate or record electrophysiological or
neurochemical activity in nervous tissue is rapidly expanding. Despite remarkable results in …

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

I Farhy-Tselnicker, NJ Allen - Neural development, 2018 - Springer
In the mammalian cerebral cortex neurons are arranged in specific layers and form
connections both within the cortex and with other brain regions, thus forming a complex …

Questions and (some) answers on reactive astrocytes

C Escartin, O Guillemaud, MA Carrillo‐de Sauvage - Glia, 2019 - Wiley Online Library
Astrocytes are key cellular partners for neurons in the central nervous system. Astrocytes
react to virtually all types of pathological alterations in brain homeostasis by significant …

Human astrocytes: structure and functions in the healthy brain

F Vasile, E Dossi, N Rouach - Brain Structure and Function, 2017 - Springer
Data collected on astrocytes' physiology in the rodent have placed them as key regulators of
synaptic, neuronal, network, and cognitive functions. While these findings proved highly …

[HTML][HTML] Lactate and BDNF: key mediators of exercise induced neuroplasticity?

P Müller, Y Duderstadt, V Lessmann… - Journal of Clinical …, 2020 - mdpi.com
Accumulating evidence from animal and human studies supports the notion that physical
exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative …

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

L Hösli, N Binini, KD Ferrari, L Thieren, ZJ Looser… - Cell reports, 2022 - cell.com
The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and
memory are still poorly explored. Astrocytes form large intercellular networks by gap junction …

[HTML][HTML] Lactate as a metabolite and a regulator in the central nervous system

P Proia, CM Di Liegro, G Schiera, A Fricano… - International journal of …, 2016 - mdpi.com
More than two hundred years after its discovery, lactate still remains an intriguing molecule.
Considered for a long time as a waste product of metabolism and the culprit behind …