Triosephosphate isomerase: a highly evolved biocatalyst
RK Wierenga, EG Kapetaniou… - Cellular and molecular life …, 2010 - Springer
Triosephosphate isomerase (TIM) is a perfectly evolved enzyme which very fast
interconverts dihydroxyacetone phosphate and d-glyceraldehyde-3-phosphate. Its catalytic …
interconverts dihydroxyacetone phosphate and d-glyceraldehyde-3-phosphate. Its catalytic …
A role for flexible loops in enzyme catalysis
Triosephosphate isomerase (TIM), glycerol 3-phosphate dehydrogenase, and orotidine 5′-
monophosphate decarboxylase each use the binding energy from the interaction of …
monophosphate decarboxylase each use the binding energy from the interaction of …
Enzyme architecture: on the importance of being in a protein cage
Highlights•Substrate binding occludes water from the active sites of enzymes.•KSI binds
steroid substrates at a solvent exposed cleft.•TIM binds substrate at an open cage.•DAP …
steroid substrates at a solvent exposed cleft.•TIM binds substrate at an open cage.•DAP …
Antileishmanial phytochemical phenolics: molecular docking to potential protein targets
IV Ogungbe, WR Erwin, WN Setzer - Journal of Molecular Graphics and …, 2014 - Elsevier
A molecular docking analysis has been carried out to examine potential Leishmania protein
targets of antiprotozoal plant-derived polyphenolic compounds. A total of 352 phenolic …
targets of antiprotozoal plant-derived polyphenolic compounds. A total of 352 phenolic …
In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids
IV Ogungbe, WN Setzer - Molecules, 2013 - mdpi.com
Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in
resource-limited countries. The mortality associated with these diseases is largely due to …
resource-limited countries. The mortality associated with these diseases is largely due to …
Experimental structure based drug design (SBDD) applications for anti‐leishmanial drugs: A paradigm shift?
M Marín, M López, L Gallego‐Yerga… - Medicinal Research …, 2024 - Wiley Online Library
Leishmaniasis is a group of neglected tropical diseases caused by at least 20 species of
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …
Leishmania protozoa, which are spread by the bite of infected sandflies. There are three …
A paradigm for enzyme-catalyzed proton transfer at carbon: triosephosphate isomerase
JP Richard - Biochemistry, 2012 - ACS Publications
Triosephosphate isomerase (TIM) catalyzes the stereospecific 1, 2-proton shift at
dihydroxyacetone phosphate (DHAP) to give (R)-glyceraldehyde 3-phosphate through a …
dihydroxyacetone phosphate (DHAP) to give (R)-glyceraldehyde 3-phosphate through a …
'Negative'and 'positive catalysis': complementary principles that shape the catalytic landscape of enzymes
Our understanding of enzyme catalysis is dominated by transition state theory. According to
this concept, an enzymatic reaction is guided along a desired reaction coordinate through …
this concept, an enzymatic reaction is guided along a desired reaction coordinate through …
The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases—Part III: In-silico molecular docking investigations
IV Ogungbe, WN Setzer - Molecules, 2016 - mdpi.com
Malaria, leishmaniasis, Chagas disease, and human African trypanosomiasis continue to
cause considerable suffering and death in develo** countries. Current treatment options …
cause considerable suffering and death in develo** countries. Current treatment options …
The activating oxydianion binding domain for enzyme-catalyzed proton transfer, hydride transfer, and decarboxylation: Specificity and enzyme architecture
The kinetic parameters for activation of yeast triosephosphate isomerase (Sc TIM), yeast
orotidine monophosphate decarboxylase (Sc OMPDC), and human liver glycerol 3 …
orotidine monophosphate decarboxylase (Sc OMPDC), and human liver glycerol 3 …