The health effects of vitamin D supplementation: evidence from human studies

R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …

Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Genome-wide patterns of selection in 230 ancient Eurasians

I Mathieson, I Lazaridis, N Rohland, S Mallick… - Nature, 2015 - nature.com
Ancient DNA makes it possible to observe natural selection directly by analysing samples
from populations before, during and after adaptation events. Here we report a genome-wide …

Vitamin D for health: a global perspective

A Hossein-nezhad, MF Holick - Mayo clinic proceedings, 2013 - Elsevier
It is now generally accepted that vitamin D deficiency is a worldwide health problem that
affects not only musculoskeletal health but also a wide range of acute and chronic diseases …

Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue …

P Lips, KD Cashman, C Lamberg-Allardt… - European journal of …, 2019 - academic.oup.com
Vitamin D deficiency (serum 25-hydroxyvitamin D (25 (OH) D)< 50 nmol/L or 20 ng/mL) is
common in Europe and the Middle East. It occurs in< 20% of the population in Northern …

The role of vitamin D in reducing cancer risk and progression

D Feldman, AV Krishnan, S Swami… - Nature reviews …, 2014 - nature.com
Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low‐and middle‐income countries

DE Roth, SA Abrams, J Aloia, G Bergeron… - 2018 - Wiley Online Library
Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory
illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many …

[HTML][HTML] Vitamin D and immune function

B Prietl, G Treiber, TR Pieber, K Amrein - Nutrients, 2013 - mdpi.com
Vitamin D metabolizing enzymes and vitamin D receptors are present in many cell types
including various immune cells such as antigen-presenting-cells, T cells, B cells and …

An update on vitamin D metabolism

F Saponaro, A Saba, R Zucchi - International journal of molecular …, 2020 - mdpi.com
Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone
homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been …