GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Long-term potentiation (LTP) of synaptic transmission is considered to be a cellular
counterpart of learning and memory. Activation of postsynaptic NMDA type glutamate …

Here, we presented an integrative database named DrLLPS (http://llps. biocuckoo. cn/) for
proteins involved in liquid–liquid phase separation (LLPS), which is a ubiquitous and crucial …

The assembly of macromolecules on the plasma membrane concentrates cell surface
biomolecules into nanometer-to micrometer-scale clusters (nano-or microdomains) that help …

The intracellular environment is partitioned into functionally distinct compartments
containing specific sets of molecules and reactions. Biomolecular condensates, also …

Chromatin is spatially organized into three-dimensional structures at different levels
including A/B compartments, topologically associating domains and loops. The canonical …

MAGUK scaffold proteins play a central role in maintaining and modulating synaptic
signaling, providing a framework to retain and position receptors, signaling molecules, and …

N-methyl-D-aspartate receptors (NMDARs) are essential for excitatory neurotransmission
and synaptic plasticity. GluN2A and GluN2B, two predominant Glu2N subunits of NMDARs …

The postsynaptic density (PSD) of excitatory synapses is built from a wide variety of
scaffolding proteins, receptors, and signaling molecules that collectively orchestrate synaptic …

Once considered only scaffolding proteins at glutamatergic postsynaptic density (PSD),
Homer1 proteins are increasingly emerging as multimodal adaptors that integrate different …