Myocardial ischemia-reperfusion injury: a neglected therapeutic target
DJ Hausenloy, DM Yellon - The Journal of clinical …, 2013 - Am Soc Clin Investig
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …
Evolving therapies for myocardial ischemia/reperfusion injury
The damage inflicted on the myocardium during acute myocardial infarction is the result of 2
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …
processes: ischemia and subsequent reperfusion (ischemia/reperfusion injury). During the …
An improved MR imaging technique for the visualization of myocardial infarction
OP Simonetti, RJ Kim, DS Fieno, HB Hillenbrand, E Wu… - Radiology, 2001 - pubs.rsna.org
PURPOSE: To design a segmented inversion-recovery turbo fast low-angle shot
(turboFLASH) magnetic resonance (MR) imaging pulse sequence for the visualization of …
(turboFLASH) magnetic resonance (MR) imaging pulse sequence for the visualization of …
Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel
After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema,
inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and …
inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and …
Postconditioning the human heart
Background—In animal models, brief periods of ischemia performed just at the time of
reperfusion can reduce infarct size, a phenomenon called postconditioning. In this …
reperfusion can reduce infarct size, a phenomenon called postconditioning. In this …
Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial
S Janssens, C Dubois, J Bogaert, K Theunissen… - The Lancet, 2006 - thelancet.com
Background The benefit of reperfusion therapies for ST-elevation acute myocardial infarction
(STEMI) is limited by post-infarction left-ventricular (LV) dysfunction. Our aim was to …
(STEMI) is limited by post-infarction left-ventricular (LV) dysfunction. Our aim was to …
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions
SK Sanganalmath, R Bolli - Circulation research, 2013 - Am Heart Assoc
Despite significant therapeutic advances, the prognosis of patients with heart failure (HF)
remains poor, and current therapeutic approaches are palliative in the sense that they do not …
remains poor, and current therapeutic approaches are palliative in the sense that they do not …
Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report
DJ Pennell, UP Sechtem, CB Higgins… - European heart …, 2004 - academic.oup.com
Cardiovascular magnetic resonance (CMR) is established in clinical practice for the
diagnosis and management of diseases of the cardiovascular system. However, current …
diagnosis and management of diseases of the cardiovascular system. However, current …
No-reflow phenomenon
SH Rezkalla, RA Kloner - Circulation, 2002 - Am Heart Assoc
appeared to plug the capillary lumen. 13 Cellular edema compressing the capillaries was
confirmed in more than one experiment. 10, 21, 22 This may explain the occasional benefit …
confirmed in more than one experiment. 10, 21, 22 This may explain the occasional benefit …
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction
A Schmidt, CF Azevedo, A Cheng, SN Gupta… - Circulation, 2007 - Am Heart Assoc
Background—The extent of the peri-infarct zone by magnetic resonance imaging (MRI) has
been related to all-cause mortality in patients with coronary artery disease. This relationship …
been related to all-cause mortality in patients with coronary artery disease. This relationship …