Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Hepatic cholesterol transport and its role in non-alcoholic fatty liver disease and atherosclerosis

H Li, XH Yu, X Ou, XP Ouyang, CK Tang - Progress in lipid research, 2021 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

EM Maguire, SWA Pearce, Q **ao - Vascular Pharmacology, 2019 - Elsevier
During atherosclerosis, the gradual accumulation of lipids into the subendothelial space of
damaged arteries results in several lipid modification processes followed by macrophage …

ABC family transporters

X Liu - Drug transporters in drug disposition, effects and …, 2019 - Springer
The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

The role of macrophages in the pathogenesis of atherosclerosis

AV Blagov, AM Markin, AI Bogatyreva, TV Tolstik… - Cells, 2023 - mdpi.com
A wide variety of cell populations, including both immune and endothelial cells, participate in
the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special …

Cholesterol transport system: an integrated cholesterol transport model involved in atherosclerosis

XH Yu, DW Zhang, XL Zheng, CK Tang - Progress in Lipid Research, 2019 - Elsevier
Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Familial hypercholesterolemia: the most frequent cholesterol metabolism disorder caused disease

A Benito-Vicente, KB Uribe, S Jebari… - International journal of …, 2018 - mdpi.com
Cholesterol is an essential component of cell barrier formation and signaling transduction
involved in many essential physiologic processes. For this reason, cholesterol metabolism …

Polyphenols, saponins and phytosterols in lentils and their health benefits: an overview

AM Mustafa, D Abouelenein, L Acquaticci… - Pharmaceuticals, 2022 - mdpi.com
The lentil (Lens culinaris L.) is one of the most important legumes (family, Fabaceae). It is a
natural functional food rich in many bioactive compounds, such as polyphenols, saponins …

Egg consumption and cardiovascular risk: a dose–response meta-analysis of prospective cohort studies

J Godos, A Micek, T Brzostek, E Toledo… - European journal of …, 2021 - Springer
Purpose Cardiovascular disease (CVD) is a leading cause of mortality globally and is
strongly influenced by dietary risk factors. The aim was to assess the association between …