Regulation of neuronal GABAB receptor functions by subunit composition
M Gassmann, B Bettler - Nature Reviews Neuroscience, 2012 - nature.com
GABAB receptors (GABABRs) are G protein-coupled receptors for GABA, the main inhibitory
neurotransmitter in the CNS. In the past 5 years, notable advances have been made in our …
neurotransmitter in the CNS. In the past 5 years, notable advances have been made in our …
[HTML][HTML] Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system
D Jeremic, I Sanchez-Rodriguez… - Pharmacology & …, 2021 - Elsevier
G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …
Role of GABAB receptors in learning and memory and neurological disorders
CF Heaney, JW Kinney - Neuroscience & Biobehavioral Reviews, 2016 - Elsevier
Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …
behavior, these results often do not correspond well. These differences could be due to the …
The evolving understanding of dopamine neurons in the substantia nigra and ventral tegmental area
In recent years, the population of neurons in the ventral tegmental area (VTA) and substantia
nigra (SN) has been examined at multiple levels. The results indicate that the projections …
nigra (SN) has been examined at multiple levels. The results indicate that the projections …
Neuronal G protein-gated K+ channels
H Luo… - American Journal of …, 2022 - journals.physiology.org
G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …
Methamphetamine-evoked depression of GABAB receptor signaling in GABA neurons of the VTA
CL Padgett, AL Lalive, KR Tan, M Terunuma… - Neuron, 2012 - cell.com
Psychostimulants induce neuroadaptations in excitatory and fast inhibitory transmission in
the ventral tegmental area (VTA). Mechanisms underlying drug-evoked synaptic plasticity of …
the ventral tegmental area (VTA). Mechanisms underlying drug-evoked synaptic plasticity of …
New insights into the therapeutic potential of Girk channels
G protein-dependent signaling pathways control the activity of excitable cells of the nervous
system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and …
system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and …
Repeated cocaine weakens GABAB-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex
Repeated cocaine exposure triggers adaptations in layer 5/6 glutamatergic neurons in the
medial prefrontal cortex (mPFC) that promote behavioral sensitization and drug-seeking …
medial prefrontal cortex (mPFC) that promote behavioral sensitization and drug-seeking …
Mechanisms of cannabinoid CB2 receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area
Background We have recently reported that activation of cannabinoid type 2 receptors (CB 2
Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA) …
Rs) reduces dopamine (DA) neuron excitability in mouse ventral tegmental area (VTA) …
[HTML][HTML] Complexes of ghrelin GHS-R1a, GHS-R1b, and dopamine D1 receptors localized in the ventral tegmental area as main mediators of the dopaminergic effects …
Ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R1a), is
coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but …
coexpressed with its truncated isoform GHS-R1b, which does not bind ghrelin or signal, but …