The perspective for next-generation lung replacement therapies: functional whole lung generation by blastocyst complementation

D Shimizu, A Miura, M Mori - Current Opinion in Organ …, 2024 - journals.lww.com
While functional lungs have been generated via intraspecies blastocyst complementation,
the generation of functional interspecific lungs remains unrealized. Addressing the …

The bone marrow of mouse-rat chimeras contains progenitors of multiple pulmonary cell lineages

E Li, B Wen, D Gao, TR Kalin, G Wang… - Frontiers in Cell and …, 2024 - frontiersin.org
Radiation-induced lung injury (RILI) is a common complication of anti-cancer treatments for
thoracic and hematologic malignancies. Bone marrow (BM) transplantation restores …

Transplantation of Alveolar Macrophages Improves the Efficacy of Endothelial Progenitor Cell Therapy in Mouse Model of Bronchopulmonary Dysplasia

AN Mohammed, F Kohram, YW Lan… - … of Physiology-Lung …, 2024 - journals.physiology.org
Bronchopulmonary dysplasia (BPD) is a severe complication of preterm births, which
develops due to exposure to supplemental oxygen and mechanical ventilation. Published …

[PDF][PDF] Can a Rat Breathe through a Mouse's Lung?

M Mori, WV Cardoso - American Journal of Respiratory and Critical …, 2024 - atsjournals.org
Recent headlines of genetically modified large animals serving as organ donors have
sparked hopes in terminally ill patients in desperate need of organs for transplantation1-3 …

[PDF][PDF] Interspecies Blastocyst Complementation and the Genesis of Chimeric Solid Human Organs

E Bigliardi, AV Shetty, WC Low, CJ Steer - 2025 - preprints.org
Solid organ transplantation remains a life-saving treatment for patients worldwide.
Unfortunately, the supply of donor organs cannot meet the current need, making the search …