The role of Ca2+ signaling in Parkinson's disease
SV Zaichick, KM McGrath… - Disease models & …, 2017 - journals.biologists.com
Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …
to respond and adapt to constantly changing environments. In multicellular organisms, it …
The role of ATP13A2 in Parkinson's disease: clinical phenotypes and molecular mechanisms
JS Park, NF Blair, CM Sue - Movement Disorders, 2015 - Wiley Online Library
The importance of ATP13A2 (PARK9) in Parkinson's disease (PD) has emerged with the
discovery that mutations in this gene cause Kufor‐Rakeb syndrome, an autosomal …
discovery that mutations in this gene cause Kufor‐Rakeb syndrome, an autosomal …
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
Lysosomal dysfunction plays a central role in the pathogenesis of several
neurodegenerative disorders, including Parkinson's disease (PD). Several genes linked to …
neurodegenerative disorders, including Parkinson's disease (PD). Several genes linked to …
Parkinson's disease-associated human ATP13A2 (PARK9) deficiency causes zinc dyshomeostasis and mitochondrial dysfunction
JS Park, B Koentjoro, D Veivers… - Human molecular …, 2014 - academic.oup.com
Abstract Human ATP13A2 (PARK9), a lysosomal type 5 P-type ATPase, has been
associated with autosomal recessive early-onset Parkinson's disease (PD). ATP13A2 …
associated with autosomal recessive early-onset Parkinson's disease (PD). ATP13A2 …
ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion
R Wang, J Tan, T Chen, H Han, R Tian, Y Tan… - Journal of Cell …, 2019 - rupress.org
Mutations in ATP13A2 cause Kufor-Rakeb syndrome, an autosomal recessive form of
juvenile-onset atypical Parkinson's disease (PD). Recent work tied ATP13A2 to autophagy …
juvenile-onset atypical Parkinson's disease (PD). Recent work tied ATP13A2 to autophagy …
[HTML][HTML] Moving towards a new era of genomics in the neuronal ceroid lipofuscinoses
The neuronal ceroid lipofuscinoses (NCL) are a group of disorders defined by shared
clinical and pathological features, including seizures and progressive decline in vision …
clinical and pathological features, including seizures and progressive decline in vision …
Age-and α-synuclein-dependent degeneration of dopamine and noradrenaline neurons in the annual killifish Nothobranchius furzeri
H Matsui, N Kenmochi, K Namikawa - Cell Reports, 2019 - cell.com
Parkinson's disease (PD) is a neurodegenerative disease characterized by α-synuclein-
positive inclusion bodies and loss of neurons, including dopaminergic neurons. Difficulty in …
positive inclusion bodies and loss of neurons, including dopaminergic neurons. Difficulty in …
The LRRK2–macroautophagy axis and its relevance to Parkinson's disease
C Manzoni - Biochemical Society Transactions, 2017 - portlandpress.com
A wide variety of different functions and an impressive array of interactors have been
associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the …
associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the …
[HTML][HTML] P5B-ATPases in the mammalian polyamine transport system and their role in disease
Polyamines (PAs) are physiologically relevant molecules that are ubiquitous in all
organisms. The vitality of PAs to the healthy functioning of a cell is due to their polycationic …
organisms. The vitality of PAs to the healthy functioning of a cell is due to their polycationic …
The Roles of ATP13A2 Gene Mutations Leading to Abnormal Aggregation of α-Synuclein in Parkinson's Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease. PARK9
(also known as ATP13A2) is recognized as one of the key genes that cause PD, and a …
(also known as ATP13A2) is recognized as one of the key genes that cause PD, and a …