Oestradiol as a neuromodulator of learning and memory

LR Taxier, KS Gross, KM Frick - Nature Reviews Neuroscience, 2020 - nature.com
Although hormones such as glucocorticoids have been broadly accepted in recent decades
as general neuromodulators of memory processes, sex steroid hormones such as the potent …

Structural plasticity of the hippocampus in response to estrogens in female rodents

PAS Sheppard, E Choleris, LAM Galea - Molecular brain, 2019 - Springer
It is well established that estrogens affect neuroplasticity in a number of brain regions. In
particular, estrogens modulate and mediate spine and synapse formation as well as …

Sex differences in the brain: Implications for behavioral and biomedical research

E Choleris, LAM Galea, F Sohrabji, KM Frick - … & Biobehavioral Reviews, 2018 - Elsevier
Biological differences between males and females are found at multiple levels. However,
females have too often been under-represented in behavioral neuroscience research, which …

[HTML][HTML] The role of estrogen in brain and cognitive aging

JK Russell, CK Jones, PA Newhouse - Neurotherapeutics, 2019 - Elsevier
There are 3 common physiological estrogens, of which estradiol (E2) is seen to decline
rapidly over the menopausal transition. This decline in E2 has been associated with a …

A role for estrogen in schizophrenia: clinical and preclinical findings

A Gogos, AM Sbisa, J Sun, A Gibbons… - International journal …, 2015 - Wiley Online Library
Gender differences in schizophrenia have been extensively researched and it is being
increasingly accepted that gonadal steroids are strongly attributed to this phenomenon. Of …

Blockade of estrogen by hormonal contraceptives impairs fear extinction in female rats and women

BM Graham, MR Milad - Biological psychiatry, 2013 - Elsevier
BACKGROUND: Fear extinction is a laboratory model of fear inhibition and is the basis of
exposure therapy for anxiety disorders. Emerging evidence from naturally cycling female …

Sex differences in hippocampal function

WA Koss, KM Frick - Journal of neuroscience research, 2017 - Wiley Online Library
Sex differences in the function of the hippocampus have been observed in numerous
mammalian species. However, the magnitude, extent, and specificity of these differences are …

Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents

KM Frick, J Kim, JJ Tuscher, AM Fortress - Learning & Memory, 2015 - learnmem.cshlp.org
Ample evidence has demonstrated that sex steroid hormones, such as the potent estrogen
17β-estradiol (E2), affect hippocampal morphology, plasticity, and memory in male and …

Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms.

BS McEwen, KT Akama, JL Spencer-Segal… - Behavioral …, 2012 - psycnet.apa.org
From its origins in how the brain controls the endocrine system via the hypothalamus and
pituitary gland, neuroendocrinology has evolved into a science that now includes hormone …

Why estrogens matter for behavior and brain health

LAM Galea, KM Frick, E Hampson, F Sohrabji… - Neuroscience & …, 2017 - Elsevier
Abstract The National Institutes of Health (NIH) has required the inclusion of women in
clinical studies since 1993, which has enhanced our understanding of how biological sex …