Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

The brain is arguably the most complex organ. The branched and extended morphology of
nerve cells, their subcellular complexity, the multiplicity of brain cell types as well as their …

Action potentials trigger neurotransmitter release at the presynaptic active zone with
spatiotemporal precision. This is supported by protein machinery that mediates synaptic …

Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic
vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated …

The active zone of a presynaptic nerve terminal defines sites for neurotransmitter release. Its
protein machinery may be organized through liquid–liquid phase separation, a mechanism …

Glutamatergic synapses display variable strength and diverse short-term plasticity (STP),
even for a given type of connection. Using nonnegative tensor factorization and …

Highlights• We are only beginning to understand the mechanisms of active zone assembly.•
Trafficking, protein complex assembly, and membrane anchoring mechanisms are needed.• …

How can exactly six SNARE complexes be assembled under each synaptic vesicle? Here
we report cryo-EM crystal structures of the core domain of Munc13, the key chaperone that …

Neuronal communication across synapses relies on neurotransmitter release from
presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic …