[HTML][HTML] Current understanding of asthma pathogenesis and biomarkers

N Habib, MA Pasha, DD Tang - Cells, 2022‏ - mdpi.com
Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations)
and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have …

Understanding asthma phenotypes, endotypes, and mechanisms of disease

ME Kuruvilla, FEH Lee, GB Lee - Clinical reviews in allergy & immunology, 2019‏ - Springer
The model of asthma as a single entity has now been replaced by a much more complex
biological network of distinct and interrelating inflammatory pathways. The term asthma is …

Recent advances in severe asthma: from phenotypes to personalized medicine

N Schoettler, ME Strek - Chest, 2020‏ - Elsevier
This review focuses on recent clinical and translational discoveries in severe and
uncontrolled asthma that now enable phenoty** and personalized therapies in these …

T2-“low” asthma: overview and management strategies

AM Fitzpatrick, BE Chipps, F Holguin… - The Journal of Allergy and …, 2020‏ - Elsevier
Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …

[HTML][HTML] The impact of tobacco cigarettes, va** products and tobacco heating products on oxidative stress

R Emma, M Caruso, D Campagna, R Pulvirenti… - Antioxidants, 2022‏ - mdpi.com
Cells constantly produce oxidizing species because of their metabolic activity, which is
counteracted by the continuous production of antioxidant species to maintain the …

Mechanisms of non-type 2 asthma

SN Hudey, DK Ledford, JC Cardet - Current opinion in immunology, 2020‏ - Elsevier
Non-type 2 inflammation (Non-T2)-mediated asthma is difficult to define due to lack of
signature biomarkers. It exists in the absence of T2-high or eosinophilic inflammation and …

Genomic predictors of asthma phenotypes and treatment response

N Hernandez-Pacheco, M Pino-Yanes… - Frontiers in …, 2019‏ - frontiersin.org
Asthma is a complex respiratory disease considered as the most common chronic condition
in children. A large genetic contribution to asthma susceptibility is predicted by the clustering …

The conduct and reporting of mediation analysis in recently published randomized controlled trials: results from a methodological systematic review

TT Vo, C Superchi, I Boutron, S Vansteelandt - Journal of clinical …, 2020‏ - Elsevier
Objectives To describe the methodological characteristics of mediation analyses (MAs)
reported in recent randomized controlled trials (RCTs) and to propose recommendations on …

The effect of e-cigarette aerosol emissions on respiratory health: a narrative review

R Polosa, R O'Leary, D Tashkin, R Emma… - Expert review of …, 2019‏ - Taylor & Francis
Introduction: Due to the uptake in the use of e-cigarettes (ECs), evidence on their health
effects is needed to inform health care and policy. Some regulators and health professionals …

Role of Th17 cytokines in airway remodeling in asthma and therapy perspectives

V Margelidon-Cozzolino, A Tsicopoulos… - Frontiers in …, 2022‏ - frontiersin.org
Airway remodeling is a frequent pathological feature of severe asthma leading to permanent
airway obstruction in up to 50% of cases and to respiratory disability. Although structural …