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The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
antibiotics are becoming less effective against these bacteria, such that we risk entering a …
Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Rescuing the last-line polymyxins: achievements and challenges
Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …
Epidemiology and treatment of multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa infections
In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …
[HTML][HTML] Development and challenges of antimicrobial peptides for therapeutic applications
More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
been approved by the US Food and Drug Administration (FDA). Now commercialized, these …
Colistin Resistance in Acinetobacter baumannii: Molecular Mechanisms and Epidemiology
K Novović, B Jovčić - Antibiotics, 2023 - mdpi.com
Acinetobacter baumannii is recognized as a clinically significant pathogen causing a wide
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the …
spectrum of nosocomial infections. Colistin was considered a last-resort antibiotic for the …
A review on colistin resistance: an antibiotic of last resort
Antibiotic resistance has emerged as a significant global public health issue, driven by the
rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously …
rapid adaptation of microorganisms to commonly prescribed antibiotics. Colistin, previously …
Strategies to access biosynthetic novelty in bacterial genomes for drug discovery
F Hemmerling, J Piel - Nature Reviews Drug Discovery, 2022 - nature.com
Bacteria provide a rich source of natural products with potential therapeutic applications,
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
such as novel antibiotic classes or anticancer drugs. Bioactivity-guided screening of …
NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …
including environmental sensitivity, high reactivity toward amines and biothiols (including …
Global colistin use: a review of the emergence of resistant Enterobacterales and the impact on their genetic basis
U Binsker, A Käsbohrer… - FEMS Microbiology …, 2022 - academic.oup.com
The dramatic global rise of MDR and XDR Enterobacterales in human medicine forced
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …
clinicians to the reintroduction of colistin as last-resort drug. Meanwhile, colistin is used in …